柴人傑

發布者：吳志龍發布時間：2019-08-18浏覽次數：21212

  

    課題組長：柴人傑，bet356在线官方网站

    研究領域：神經幹細胞和内耳幹細胞的轉錄調控機制，聽覺神經元和毛細胞再生

    地址：南京市玄武區四牌樓2号，bet356在线官方网站李文正樓北231室，210096

    電話： 028-83790771; 18805193999

       Email： Renjiec@seu.edu.cn



研究組長簡介：

柴人傑，1982年11月出生，bet356在线官方网站二級教授，博士生導師，副院長；現任中國生物物理學會聽覺、言語與交流分會副會長；中國生理學會幹細胞與神經分會秘書長，常務理事；國際耳内科醫師協會執委（Executive board member）；中國聽力醫學發展基金會專家指導委員會常務委員，聽覺基礎研究專委會副主委；中國醫促會耳内科分會聽覺基礎研究學組組長；中國老年醫學學會耳科學分會常務委員；常務理事和生物醫藥專委會副主委，秘書長；江蘇省發育生物學會常務理事，青年委員會主委和聽覺科學專委會主委；江蘇省雙創聯合會常務理事和生物醫藥專委會副秘書長；中國研究型醫學會神經再生與修複專委會委員；江蘇省神經生物學會理事；美國耳鼻喉研究學會會員；國際幹細胞研究學會會員，江蘇省防聾治聾技術指導專家組委員。先後作為課題負責人主持科技部國家重點研發計劃幹細胞及轉化研究重點專項和科技部青年973計劃，主持多項國家級項目，國家自然科學基金委面上項目，人力資源和社會保障部留學人員科技活動重點項目，教育部留學人員項目，全球二十強藥企德國Boehringer Ingelheim 公司的500萬元的Faculty Research Award和瑞士Novartis公司70萬元Faculty Research Award等15項課題。相關工作發表在Advanced Materials, Nature communications, Sciences Advances, Advanced Functional Materials,3篇PNAS，Autophagy，Biomaterials, ACS Applied Materials & Interfaces, Antioxidants & Redox Signaling, 2篇Development，Drug Delivery，Cell Death & Disease，Molecular Neurobiology等有國際影響力的學術期刊上，近5年發表SCI論文72篇（總影響因子481.8）；其中第一和通訊作者論文47篇（總影響因子292.5，其中IF>10分5篇）；作為主編出版專著人工聽覺技術概要，研究成果被國際科學網站和權威期刊多次正面評價和引用；另有國際會議大會發言6次，國際會議論文21篇，作為大會主席參與舉辦了三屆中國聽覺科學大會（第1,3,4屆），作為分論壇主席主持了一屆國際耳内科醫師學會年會聽覺異常與平衡障礙分論壇（第19屆），主持了兩屆中國生物物理學會年會聽覺研究分論壇（第16,17屆），主持了一屆中國神經科學學會年會聽覺研究分論壇（第12屆）。現任SCI期刊American Journal of Stem Cells(AJSC) 執行主編 (Executive Editor-in-Chief)，American Journal of Translational Research（AJTR），Hearing Research，Frontiers of Medicine，Global Journal of Otolaryngology，Engineering和Journal of Otorhinolaryngology, Hearing and Balance Medicine（OHBM）期刊編委(Editorial Board Member)，Neural Plasticity 期刊Lead Guest Editor。


研究内容：長期緻力于神經元和内耳毛細胞的再生和保護以及神經幹細胞和内耳幹細胞的轉錄調控機制的研究。主要研究内容包括：1.系統的研究了多種信号通路對于内耳幹細胞和神經幹細胞增殖和分化的轉錄調控機制；2.結合多基因協同調控，生物材料和電刺激，磁刺激等物理調控因素有效促進神經元和毛細胞的再生和聽覺功能的部分重建；3通過調控自噬，線粒體功能和氧化應激有效的保護了噪音和藥物導緻的毛細胞損傷和聽力損失。


代表性論著

專著：

  1. 柴人傑（主編），陳峰，陳傑，戴豔紅，高下（主編），陸玲，麻曉峰，王俊國，錢曉雲，楊烨，俞晨傑，張莎莎，周函，朱光潔，人工聽覺技術概要，南京大學出版社, 352千字，ISBN 978-7-305-17890-0，2016


代表性期刊論文：

  1. Yan Liu#, Jieyu Qi#, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*（并列通訊作者）, Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, In Press, 2019(IF: 11.514)

  2. Zhongmin Liu#, Mingliang Tang#, Jinping Zhao, Renjie Chai*（并列通訊作者）, Jiuhong Kang*. Looking into the Future: Towards Advanced Three-Dimensional Biomaterials for Stem Cell-Based Regenerative Medicine. Advanced Materials, 1705388, 2018(IF:21.950)

  1. Luoran Shang, Yunru Yu, Wei Gao, Yuetong Wang, Liangliang Qu, Ze Zhao, Renjie Chai*（并列通訊作者）, Yuanjin Zhao*. Bio-inspired Anisotropic Wettability Surface from Dynamic Ferrofluid Assembled Templates. Advanced Functional Materials, 1705802, 2018(IF:13.325)

  2. Sana Shaikh, Fawad Rehman, Tianyu Du, Hui Jiang, Lihong Yin, Xuemei Wang*, Renjie Chai*（并列通訊作者）. Real-time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters.ACS Applied Materials & Interfaces, doi: 10.1021/acsami.8b08975, 2018 (IF:8.097) 

  3. Wenwen Liu, Xiaochen Xu, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Xue Wang, Shasha Zhang, Mingliang Tang, Jianfeng Li, Renjie Chai*（并列通訊作者）, Haibo Wang*.Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea.Antioxidants & Redox Signaling, doi: 10.1089/ars.2017.7288, 2018 (IF:6.530)

  4. Wenqing Yan#, Wenwen Liu#, Jieyu Qi, Qiaojun Fang, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Jianfeng Li, Fangyi Chen, Dong Liu*, Renjie Chai*（并列通訊作者）, Haibo Wang*. A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro.Molecular Neurobiology, 55(3):2070-2084., 2018(IF:6.19)

  5. Zuhong He#, Lingna Guo#, Yilai Shu#, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, Suhua Sha, Huawei Li*, Xia Gao*, Renjie Chai*（并列通訊作者）. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy, 2:1-21, 2017(IF:11.100)

  6. Shasha Zhang, Yuan Zhang, Pengfei Yu, Yao Hu, Han Zhou, Lingna Guo, Xiaochen Xu, Xiaocheng Zhu, Muhammad Waqas, Jieyu Qi, Xiaoli Zhang, Xiaoyun Qian, Fangyi Chen, Mingliang Tang, Yan Liu, Haibo Shi*, Xia Gao*, Renjie Chai*（并列通訊作者）. Characterization of Lgr5+ progenitor cell transcriptomes after neomycin injury in the neonatal mouse cochleae.Frontiers in Molecular Neuroscience, 10:213, 2017(IF:5.076)

  7. Xiaoling Lu#, Shan Sun#, Jieyu Qi, Wenyan Li, Liman Liu, Yanping Zhang, Yan Chen, Shasha Zhang, Lei Wang, Dengshun Miao, Renjie Chai*（并列通訊作者）, Huawei Li*. Bmi1 regulates the proliferation of cochlear supporting cells via the canonical Wnt signaling pathway. Molecular Neurobiology, 54(2):1326-1339, 2017(IF:6.19)

  8. Rongrong Guo#, Shasha Zhang#, Miao Xiao, Fuping Qian, Zuhong He, Dan Li, Xiaoli Zhang,  Huawei Li, Xiaowei Yang, Ming Wang, Renjie Chai*（并列通訊作者）, Mingliang Tang*.Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. Biomaterials, 106:193-204. 2016(IF:8.402)

  9. Liman Liu#, Yan Chen#, Jieyu Qi Yanping Zhang, Yingzi He, Wenli Ni, Wen Li, Shasha Zhang, Shan Sun, Makoto Taketo, Lei Wang, Renjie Chai*（并列通訊作者）, Huawei Li*. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.Cell Death & Disease, 10;7:e2136, 2016(IF:5.965)

  10. Tian Wang#, Renjie Chai#（并列第一作者）, Grace Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, Lindsey May, Jian Zuo, Lisa Cunningham, Alan Cheng*. Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatalmouse utricle. Nature Communications, 7;6:6613, 2015(IF:11.47)

  11. Brandon Cox#, Renjie Chai#（并列第一作者）, Anne Lenoir, Zhiyong Liu, LingLi Zhang, Duc-Huy Nguyen,Kavita Chalasani, Katherine Steigelman Jie Fang, Alan Cheng*, Jian Zuo*. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.Development, 141,816-29, 2014(IF:6.462)

  12. Taha Jan#, Renjie Chai#（并列第一作者）, Zahra Sayyid, Renée Amerongen, Anping Xia, Tian Wang,Saku Sinkkonen, Yi Zeng, Jared Levin, Stefan Heller, Roel Nusse*, Alan Cheng*.  Tympanic border cells are Wnt-responsive and act as progenitors for postnatal mouse cochlear cells. Development,140, 1196-1206, 2013(IF:6.273)

  13. Renjie Chai#, Bryan Kuo#, Tian Wang, Eric Liaw, Anping Xia, Taha Jana, Zhiyong Liu, Makoto M. Taketo, John Oghalai, Roeland Nusse, Jian Zuo*, Alan Cheng*. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A, 109(21):8167-72, 2012 (IF:9.737)




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