王福龍：副研究員
E-mail：fulongwang@seu.edu.cn
辦公地點：南京市四牌樓2号，微波樓507室
個人簡介
本科畢業于bet356在线官方网站，先後獲得中國科學院大學碩士學位和英屬哥倫比亞大學博士學位，MD安德森癌症中心和新墨西哥大學從事博士後研究，2023年9月加入bet356在线官方网站，擔任副研究員。
研究方向
酶體損傷是一種在衆多疾病中常見的細胞病變，這些疾病包括病原體感染（例如新冠病毒感染）、老年性疾病（比如神經退行性疾病）、以及環境污染（包括PM2.5微粒）相關的疾病。細胞如何在内外壓力和刺激下維持包括溶酶體在内的内部穩态平衡是其最基礎和本質的功能。本課題組旨在研究溶酶體在應激壓力下與其他細胞器或細胞結構的聯動機制以及自噬相關蛋白在其中的作用。
代表性論文
1. Wang F, Peters R, Jia J, Mudd M, Salemi M, Allers L, Javed R, Duque TLA, Paddar MA, Trosdal ES, Phinney B, Deretic V. ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion. Developmental Cell. 2023 May 22;58(10):866-884.e8.
2. Wang F, Trosdal ES, Paddar MA, Duque TLA, Allers L, Mudd M, Akepati PR, Javed R, Jia J, Salemi M, Phinney B, Deretic V. The role of ATG5 beyond Atg8ylation and autophagy. Autophagy. 2023 Oct 24;:1-3.
3. Deretic V, Wang F. Autophagy is part of the answer to tuberculosis. Nature Microbiology. 2023 May;8(5):762-763.
4. Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V. Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage. Autophagy. 2023 Jun;19(6):1893-1895.
5. Javed R, Jain A, Duque T, Hendrix E, Paddar MA, Khan S, Claude-Taupin A, Jia J, Allers L, Wang F, Mudd M, Timmins G, Lidke K, Rusten TE, Akepati PR, He Y, Reggiori F, Eskelinen EL, Deretic V. Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs. The EMBO Journal. 2023 Jun 5;:e112845.
6. Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V. Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. The Journal of Cell Biology. 2022 Nov 7;221(11).
7. Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GPD, Javed R, Gu Y, Allers L, Peters R, Wang F, da Costa LJ, Pallikkuth S, Lidke KA, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze SA, Mari MC, Johansen T, Reggiori F, Deretic V. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nature Cell Biology. 2021 Aug;23(8):846-858.
8. Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, Rodrigues B. Heparanase protects the heart against chemical or ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology. 2019 Jun; 131:29-40.
9. Wang F, Jia J, Rodrigues B. Autophagy, metabolic disease, and pathogenesis of heart dysfunction. Canadian Journal of Cardiology. 2017 Jul;33(7):850-859.
10. Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B. Heparanase overexpression induces glucagon resistance and protects animals from chemically induced diabetes. Diabetes. 2017 Jan;66(1):45-57.
11. Wang F, Jia J, Lal N, Zhang D, Chiu AP, Wan A, Vlodavsky I, Hussein B, Rodrigues B. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovascular Research. 2016 Dec;112(3):656-668.
完整文章列表：https://orcid.org/0000-0002-7083-9675
