Su Wang
Ph.D. Professor(PI)
Institute of Life Sciences, Southeast University
2 Sipailou Road, Nanjing 210096, China
Tel: 025-83790976
E-mail: wangsu@seu.edu.cn
Academic Background
2017 Feb. – Present: Professor, Institute of Life Sciences, Southeast University, P.R. China
2010 Aug. – 2015 Dec.: PhD. Student, Department of Cell Biology and Anatomy, University of Kansas Medical Center, USA
2010 Aug. – 2015 Dec.: Pre-doctoral researcher, Stowers Institute for Medical Research, USA
2006 Sept. – 2010. Jun.: B.S., School of Life Sciences, Peking University, P.R. China
Research Interests
The regulation of stem cell self-renewal and differentiation is the key to the breakthrough of stem cell therapy in clinical application. However, how does extrinsic factors from microenvironment regulate neuroblast functions is still poorly understood. Our group focuses on the mechanisms in regulating stem cell self-renewal and differentiation using Drosophila stem cell model. We are trying firstly to identify the genes or signalings that function inside stem cell or in stem cell niche formed by glia cells to control neuroblast self-renewal or differentiation. Secondly, to elucidate the regulatory mechanisms of the identified genes or signalings and how do they interact with cell fate determinants inside stem cells. Thirdly, to investigate the effects of these factors on Drosophila locomotor, learning and cognition behavior. Finally, to identify differentiation niche forming cells in mouse neural stem cell system and their regulatory functions.We aim to provide experimental evidence and theoretical foundation for the clinical application of neural stem cells in neural diseases treatment in the future.
Publications （# Co-first Author, *Corresponding Author）
Ma X, Zhu X, Han Y, Story B, Do T, Song X, Wang S, Zhang Y, Blanchette M, Gogol M, Hall K, Peak A, Anoja P, Xie T*: Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms. Developmental Cell. 2017 Apr 24; 41(2):157-169. e5. doi: 10.1016/j.devcel.2017.03.023.
Lu T#, Wang S#, Gao Y, Mao Y, Yang Z, Liu L, Song X, Ni J, Xie T*: COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development. 2015 Dec 15;142(24):4242-52.
Wang S, Gao Y, Song X, Ma X, Zhu X, Mao Y, Yang Z, Ni J, Li H, Malanowski K, Anoja P, Park J, Haug J, Xie T*.: Wnt Signaling-Mediated Redox Regulation Maintains the Germline Stem Cell Differentiation Niche. eLife. 2015 Oct 9; 4. doi: 10.7554/eLife.08174
Pan L#, Wang S#, Lu T#, Weng C, Song X, Park JK, Sun J, Yang ZH, Yu J, Tang H, McKearin DM, Chamovitz DA, Ni J, Xie T*: Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014 Oct 9; 514(7521):233-6.
Ma X, Wang S, Do T, Song X, Inaba M, Nishimoto Y, Liu LP, Gao Y, Mao Y, Li H, McDowell W, Park J, Malanowski K, Peak A, Perera A, Li H, Gaudenz K, Haug J, Yamashita Y, Lin H, Ni JQ, Xie T*: Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PLoS One. 2014 Mar 21; 9(3):e90267.
Wang X#, Pan L#, Wang S#, Zhou J, McDowell W, Park J, Haug J, Staehling K, Tang H, Xie T*: Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation. PLoS Genet. 2011 Dec; 7(12):e1002426.
Kirilly D#, Wang S#, Xie T*: Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011 Dec; 138(23):5087-97.
Chen S, Wang S, Xie T*: Restricting self-renewal signals within the stem cell niche: multiple levels of control. Curr Opin Genet Dev. 2011 Dec; 21(6):684-9.
Platform and Poster Presentations on Conference
Mar 26-30, 2014. Wang S, Xie T. Wnt signaling in escort cells regulate germ cell differentiation in drosophila ovary. Oral presentation. 55th Annual Drosophila Research Conference, San,Diego, CA, USA
Mar 7-11, 2012. Wang S, Kirilly D, Xie T. Interactions between differentiated germ cells and escort cells in Drosophila ovary. Poster presentation. 53rd Annual Drosophila Research Conference, Chicago, IL, USA
