個人簡介：
畢業于南京大學生物學系，獲理學學士和碩士學位，1994年赴日本留學，2000年獲日本東京大學醫學系研究科分子細胞生物學博士學位，同年為日本學術振興會外國人特别研究員，2001年起，在美國加州大學舊金山分校(UCSF)作博士後，2004年8月起受聘為bet356在线官方网站教授。主要研究神經系統發育缺陷而緻相關神經精神疾病的發生機制。曾獲國家傑出青年科學基金資助，作為首席科學家和首席專家主持國家重點基礎研究計劃（973）以及863項目。研究工作同時受到國家自然科學基金面上及重點項目支持。曾入選首批江蘇省“333工程”中青年科技領軍人才，江蘇省特聘教授；獲江蘇省有突出貢獻中青年專家稱号；2009年入選“新世紀百千萬人才工程”國家級人選；享受國務院特殊津貼。現任中國神經科學學會理事、江蘇省發育生物學會副理事長、江蘇省解剖學會副理事長等。 研究方向：端腦發育的調控與相關神經精神疾病的病理機制 海馬、新皮層是行使腦高級功能如學習記憶、情感的重要功能區域，多種認知和情感障礙均與早期海馬以及新皮層神經環路的發育異常密切相關，但其發生發展機制尚不明了。本課題組主要利用基因工程小鼠，通過基因敲除、轉基因等手段揭示海馬和新皮層神經環路發育過程中神經幹細胞的分化、神經元遷移和成熟的調控機制，探讨環路中興奮性神經元與抑制性中間神經元二者之間的平衡維持機制，旨在為深入理解腦高級功能的神經生物學基礎及其相關疾病的發生機制提供線索。 本課題組日常負責人聯系方式： 劉琍： 025-83272362 發表論文：
1.Yang Y Shen W, Ni Y,Su Y, Yang Z, ZhaoC*. Impaired interneuron development after Foxg1 disruption. Cerebral cortex. In press. 2.Liu R, Yang Y, Shen J, Chen H, Zhang Q, Ba R, Wei Y, Li KC, Zhang X, ZhaoC*. Fstl1 is involved in the regulation of radial glial scaffold development.Molecular Brain.2015 Sep 17;8(1):53. doi: 10.1186/s13041-015-0144-8. 3.Liu J, Liu B, Zhang X, Yu B, Guan W, Wang K, Yang Y, Gong Y, Wu X, Yanagawa Y, Wu S, Zhao C*. Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex. Molecular Brain. 2014, Nov 18, 7 (1) :84 , doi:10.1186/s13041-014-0084-8. 4.Wu X, Gu X, Han X, Du A, Jiang Y, Zhang X, Wang Y, Cao G, Zhao C*. A Novel Function for FoxM1 in Interkinetic Nuclear Migration in the Developing Telencephalon And Anxiety-related Behavior. The Journal of Neuroscience. 2014 Jan; 34(4):1510-1522. 5.Huang Y, Song NN, Lan W, Zhang Q, Zhang L, Zhang L, Hu L, Chen JY, Zhao C, Li L, Xu L, Ding YQ*. Sensory input is required for callosal axon targeting in the somatosensory cortex. Mol Brain. 2013 Dec 5;6(1):53.doi: 10.1186/1756-6606-6-53. 6.Nie B, Chen K, Zhao S, Liu J, Gu X, Yao Q, Hui J, Zhang Z, Teng G, Zhao C, Shan B* . A Rat Brain MRI Template with Digital Stereotaxic Atlas of Fine Anatomical Delineations in Paxinos Space and its Automated Application in Voxel-Wise Analysis. Human Brain Mapping.2013 Jun;34(6):1306-18. 7.Tian C, Gong Y, Yang Y, Shen W, Wang K, Liu J, Xu B, Zhao J, Zhao C*. Foxg1 Has An essential Role in Postnatal Development of The Dentate gyrus. The Journal of Neuroscience. 2012. Feb., 32(9):2931-2949. 8.Gu X, Liu B, Wu X, Yan Y, Zhang Y, Wei Y,. Pleasure SJ, Zhao C*. Inducible Genetic Lineage Tracing of Cortical Hem Derived Cajal-Retzius Cells Reveals Novel Properties. PLoS ONE. 2011;6(12):e28653. 9.Li Y, Tian C, Yang Y, Yan Y, Ni Y, Wei Y, Pleasure SJ, Zhao C*. An inducible transgenic Cre mouse line for the study of hippocampal development and adult neurogenesis. Genesis. 2011 Dec. 49 (12):919-926. 10.Zhou W, Zhang Y, Li Y, Wei YS, Liu G, Liu DP, Pleasure SJ, Xie W, Zhao C*. A transgenic Cre mouse line for the study of cortical and hippocampal development.Genesis.2010 May; 48(5):343-50. 11.Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C*. The expression pattern of Follistatin-like 1 in mouse central nervous system development.. Gene Expr Patterns. 2009 Oct; 9(7):532-540. 12.Gu X, Yan Y, Li H, He D, Pleasure SJ, Zhao C*.Characterization of the Frizzled10-CreERTM Transgenic Mouse: An Inducible Cre Line for the Study of Cajal–Retzius Cell Development. Genesis. 2009 Mar; 47(3): 210 – 216. 13.Yan Y, Li Y, Hu C, Gu X, Liu J, Hu YA, Yang Y, Wei Y, Zhao C*. Expression of Frizzled10 in mouse nervous system. Gene Expr Patterns. 2009 Mar; 9 (3):173-177. 14.Hu C, Liu J, Zhang Y, Li Y, Xie W, Zhao C*. A useful transgenic mouse line for studying the development of spinal nociceptive circuits.Neuroscience lett. 2009 Jan 30; 450 (2):211-216. 15.Gu X, He D, Li Y, Hu C, Wei YS, Liu G, Liu D, Pleasure SJ, Xie W, Zhao C*. Generation of Frizzled10-Cre Transgenic Mouse Line: A Useful Tool for the Study of Dorsal Telencephalic Development. Genesis. 2008 Oct; 46 (10):523-9. 16.Hu YA, Gu X, Liu J, Yang Y, Yan Y, Zhao C*. Expression pattern of wnt inhibitor factor 1(wif1) during the development in mouse CNS. Gene Expr Patterns. 2008 Sep; 8 (7-8): 515-522. 17.Zhao C, Guan W, Pleasure SJ. A Transgenic Marker Mouse Line Labels Cajal-Retzius Cells from the Cortical Hem and Thalamocortical axons.Brain Res. 2006 Mar 10; 1077 (1):48-53. (cover story) 18.Zhao C*, Avilés C, Abel RA, Almli CR, McQuillen P, Pleasure SJ*. Hippocampal and Visuospatial Learning Defects in Mice with Deletion of Frizzled9, a Gene in the Williams Syndrome Deletion Interval.Development.2005 Jun; 132(12):2917-2927. 19.Zhao C*, Pleasure SJ*.Frizzled9 Protein Is Regionally Expressed in the Developing Medial Wall of the Cortex and the Cells Derived from This Region.Developmental Brain Research. 2005 Jun 9; 157 (1):93-97. 20.Zhao C, Pleasure SJ.The Frizzled9 Promoter Drives Expression of Transgenes in the Medial Wall of the Cortex and Its Chief Derivative the Hippocampus. Genesis.2004 Sep; 40(1):32-9. 21.Zhou CJ, Zhao C, Pleasure SJ.Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production And Radial Glial Scaffold Abnormalities. The Journal of Neuroscience. 2004 Jan 7;24(1):121-126. 22.Zhao C,Takita J, Tanaka Y, Setou M, Nakagawa T, Takeda S, Yang HW, Terada S, Nakata T, Takei Y, Saito M, Tsuji S, Hayashi Y, Hirokawa N.Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1B.Cell. 2001 Jun 1;105(5):587-597.
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