羅玉璇  教授，博士生導師

E-mail: yuxuanluo@seu.edu.cn

辦公地點：南京市四牌樓2号，李文正南樓213室

教育和工作簡曆

2005年至2009年，四川大學，生物學基地班，學士

2009年至2014年，北京協和醫學院，生物化學與分子生物學，博士

2014年至2017年，重慶醫科大學附屬第二醫院

2017年至2021年，美國德克薩斯大學西南醫學中心，博士後

2022年至今，bet356在线官方网站，beat365体育官网平台，教授

研究方向：心血管疾病發病機制

心血管疾病是人類健康的“第一殺手”，每年奪走約1790萬人的生命。目前人們對于心血管疾病的發病機制尚不完全清楚。本實驗室聚焦心肌肥厚和心肌損傷，圍繞信号通路、轉錄因子和線粒體，以小鼠為模式動物，運用生物化學與分子生物學、細胞生物學、表觀遺傳學等方法研究心血管疾病相關分子的作用機理。

近期代表性論文： （* 通訊作者; # 第一作者）

1. Yuxuan Luo, Nan Jiang, Herman I. May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Cooperative binding of ETS2 and NFAT link Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy. Circulation. 2021;144:34-51.

2. Anwarul Ferdous, Sarvjeet Singh, Yuxuan Luo, Md. J. Abedin, Nan Jiang, Cameron E. Perry, Bret M. Evers, Thomas G. Gillette, Michael Kyba, Maria Trojanowska, Joseph A. Hill. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circulation Research. 2021;129:949–964.

3. Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine , Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. Nature Communications, 2021; 12:1684.

4. Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel,Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth. Nature Communications, 2020;11:2551.

5. Yu-Xuan Luo^#, Xiaoqiang Tang^#, Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen, De-Pei Liu. Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. Eur Heart J, 2017. 38(18): p. 1389-1398.

6. Xi Jiang^#, Ke-Qiong Deng^#Yu-Xuan Luo^#, Ding-Sheng Jiang, Lu Gao, Xiao-Fei Zhang, Peng Zhang, Guang-Nian Zhao, Xueyong Zhu, Hongliang Li. Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Positive Regulator of Pathological Cardiac Hypertrophy. Hypertension, 2015. 66(2): p. 356-67.

7. Rui-Feng Yang, Li-Hong Sun, Ran Zhang, Yuan Zhang, Yu-Xuan Luo, Wei Zheng, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu. Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation. Sci Rep, 2015. 5: p. 7990.

8. Yuan Zhang, Jing Xu, Yu-Xuan Luo, Xi-Zhou An, Ran Zhang, Guang Liu, Hongliang Li, Hou-Zao Chen, De-Pei Liu. Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli. Antioxid Redox Signal, 2014. 21(12): p. 1693-707.

9. Ding-Sheng Jiang^#, Yu-Xuan Luo^#, Ran Zhang^#, Xiao-Dong Zhang, Hou-Zao Chen, Yan Zhang, Ke Chen, Shu-Min Zhang, Guo-Chang Fan, Peter P. Liu, De-Pei Liu, Hongliang Li. Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin. Hypertension, 2014. 63(1): p. 119-27.