淩琳 教授，博士生導師

電話：

E-mail: linglin1000@163.com

辦公地點：南京市四牌樓2号，李文正樓北樓215室

個人簡介：

2004-2008安徽農業大學生物科學學士，2009-2012特種經濟動物學碩士，2012-2015西北工業大學和中科院分子植物科學卓越創新中心航空宇航科學與生物技術博士，2015-2022在美國加州大學河濱分校昆蟲系擔任博士後研究員和項目科學家。2022年受聘為bet356在线官方网站教授。

研究方向：害蟲發育、生殖和行為的分子調控

蚊子傳播多種危險性疾病對人類構成巨大威脅。昆蟲在生命的各階段表現出形态重組和行為改變，以适應特定階段的發育功能和環境變化。成年雌性蚊蟲進化出的吸血繁殖策略，不僅加大了種群的擴散能力，使之成為全球性的入侵物種；也是叮咬人類、獲取和傳播病原體的根本原因和渠道。本實驗室以基因組編輯技術為基礎，整合microRNA調控、信号通路交聯、激素互作、組織通訊、體内蛋白質精準定位和生物組學大數據的交叉研究方法，解析害蟲防控的分子靶标和調控網絡。

近期代表性論文：

1.       Lin Ling, Alexander S Raikhel^*; Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito Aedes aegypti. Proceedings of the National Academy of Sciences, 2021, 118 (6): e2023470118.  

2.       Lin Ling, Alexander S Raikhel^*; Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti. Proceedings of the National Academy of Sciences, 2018, 115 (42): E9822-E9831.

3.       Lin Ling, Vladimir A Kokoza, Changyu Zhang, Emre Aksoy, Alexander S Raikhel^*; MicroRNA-277 targets insulin-like peptides 7 and 8 to control lipid metabolism and reproduction in Aedes aegypti mosquitoes. Proceedings of the National Academy of Sciences, 2017, 114 (38): E8017-E8024.

4.       Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Xu Chen, Peng Shang, Anthony A James, Yongping Huang^*, Anjiang Tan^*; MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology, 2015, 12 (7): 742-748.

5.       Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Abu Faiz Md Aslam, Qisheng Song, Peng Shang, Yongping Huang^*, Anjiang Tan^*; MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2014, 53:13-21.

6.       Lin Ling, Xuelan Liu, Jiaping Xu^*, Zhengying You, Jingbo Zhou; Silkworm eggs: An ideal model for studying the biological effects of low energy Ar⁺ ion interaction in animals. Nuclear Instruments and Methods in Physics Research B, 2011, 269(18): 1997-2000.

7.       Zulian Liu, Jun Xu, Lin Ling, Xingyu Luo, Dehong Yang, Xu Yang, Xiaoqian Zhang, Yongping Huang^*; miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signaling and cuticle protein in Bombyx mori, RNA Biology, 2020, 17(9): 1342-1351.

8.       Dujuan Dong, Yang Zhang, Vlastimil Smykal, Lin Ling, Alexander S Raikhel^*; HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction, Insect Biochemistry and Molecular Biology, 2018, 96: 19-26.

9.       Zulian Liu, Lin Ling, Jun Xu, Baosheng Zeng, Yongping Huang, Peng Shang, Anjiang Tan^*; MicroRNA-14 regulates larval development time in Bombyx mori, Insect Biochemistry and Molecular Biology, 2018, 93: 57-65.  

Bo Zhao, Keira J Lucas, Tusar T Saha, Jisu Ha, Lin Ling, Vladimir A Kokoza, Sourav Roy, Alexander S Raikhel^*; MicroRNA-275 targets sarco/endoplasmic reticulum Ca²⁺ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut, PLoS Genetics, 2017, 13(8): e1006943.