李健

博士、教授、博士生導師

電話：13052881142

Email: jianli2014@seu.edu.cn

辦公地點：四牌樓校區五五樓312室

江蘇省生物信息學專委會委員，副秘書長，江蘇省高性能計算專委會委員，中國人工智能學會生物信息學與合成生命專委會委員，中國遺傳學會高級會員

個人簡介：

1996年9月至2001年6月，就讀于bet356在线官方网站，獲臨床醫學學士學位

2001年7月至2003年3月，在中科院遺傳所進行課題研究

2004年7月至2008年11月，就讀于丹麥奧胡斯大學，獲醫學博士學位

2008年11月至2014年7月，奧胡斯大學研究助理、博士後、主要研究員

2014年7月至2020年7月，bet356在线官方网站，副研究員

2020年8月至今，bet356在线官方网站，教授

研究方向：

生物信息學及系統生物學。主要從事基因組學，測序技術研發；使用高性能計算、深度學習與基因組學研究複雜疾病及健康問題。

近期代表性論文：

1. Jian Li, Xue Lin, Mingya Wang, Yunyun Hu, Kaiyu Xue, Shuanglin Gu, Li Lv, Saijun Huang, Wei Xie, Potential Role of Genomic Imprinted Genes and Brain Developmental Related Genes in Autism, BMC Medical Genomics, 2020, Mar 26;13(1):54.

2. Mingliang Tang, Jian Li, Li He, Rongrong Guoa, Xiaoqian Yan, Dan Li, Yuhua Zhang, Menghui Liao, Buwei Shao, Yangnan Hu, Yun Liu, Qilin Tang, Lin Xia, Xing Guo, Renjie Chai, Transcriptomic profiling of neural stem cell differentiation on graphene substrates. Colloids Surf B Biointerfaces. 2019 Jun 25;182:110324. doi: 10.1016/j.colsurfb.2019.06.054. 

3. Yuzhi Wang, Xue Lin, Xue Gong, Lele Wu, Jun Zhang, Weiguang Liu, Jian Li, Liming Chen. Atypical GATA transcription factor TRPS1 represses gene expression by recruiting CHD4/NuRD(MTA2) and suppresses cell migration and invasion by repressing TP63 expression. Oncogenesis. 2018 Dec 19;7(12):96. doi: 10.1038/s41389-018-0108-9.

4. Yan Liu, Jian Li (Co-first authors), Zhifang Ma, Jun Zhang, Yuzhi Wang, Zhenghong Yu, Xue Lin, Li An, Huilin Zheng, Shuang Yu, Jingzhong Zhang, Zhi Xu, Liming Chen. Oncogenic functions of Protein Kinase D2 in regulating multiple cancer-related pathways and breast cancer. Cancer Medicine, 2019, 8:729–741.

5.  Jing Zuo, Jian Li(Co-first author, co-corresponding author), Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang, Wei Xie, Institute Collection and Analysis of Nanobodies (iCAN): a comprehensive database and analysis platform for nanobodies. BMC Genomics (2017), 18(1):797. doi: 10.1186/s12864-017-4204-6.

6. Liu Yan, Jian Li(Co-first authors), Jun Zhang, Zhenghong Yu, Shiyi Yu, Lele Wu, Yuzhi Wang, Xue Gong, Chenxi Wu, Xiuxiu Cai, Lin Mo, Mingya Wang, Jun Gu, Liming Chen. Oncogenic protein kinase D3 regulating networks in invasive breast cancer. International Journal of Biological Sciences, 2017, 13(6): 748-758.

7. Yu Xue, Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, Jianmin Wu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han, Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen, Yun Liu, Zhang Zhang, Kun Huang, Jun Yu. Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics 14 (2016) 253–261.

8. Anders Patrik Gunnarsson, Rikke Christensen, Jian Li, Uffe Birk Jensen. Global gene expression and comparison between multiple populations in the mouse epidermis, Stem Cell Res. 2016 Jul; 17(1):191-202.

9. Xue Lin, Jan Stenvang, Mads Kristoffer Heilskov Rasmussen, Shida Zhu, Guangxia Yang, Kirstine Belling, Claus Lindbjerg Andersen*, Jian Li*, Lars Bolund*, Nils Brünner*. The Potential Role of Alu Y in the Development of Resistance to SN38 (Irinotecan) and Oxaliplatin in Colon Cancer (* corresponding author), BMC Genomics, 2015, 16:404.