羅卓娟    教授

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辦公地點：李文正樓南207室

教育和工作簡曆

1998至2002年，安徽大學，學士
2002至2005年，bet356在线官方网站，碩士
2006至2011年，新加坡國立大學，博士
2011至2015年，Stowers Institute for Medical Research，博士後

2015年，     Feinberg School of Medicine, Northwestern University，博士後
2016至今，   bet356在线官方网站，生命科學院研究院，教授

研究方向：表觀遺傳調控與疾病的發生發展

    越來越多的研究表明表觀遺傳調控異常與多種發育缺陷以及疾病之間息息相關，因而長期以來受到廣泛的關注。基因組印記是指父源和母源的等位基因因表觀遺傳上的差異而造成的差異性表達。印記基因參與了衆多關鍵的信号通路，調節細胞的增殖分化以及幹細胞的全能性，在發育和疾病發生發展過程中起到重要的作用。由于其單基因表達的特點，印記基因表達水平更加容易受到遺傳，表觀遺傳以及環境波動的影響，從而造成各種先天性疾病以及癌症。本實驗室主要在多種疾病與發育模型中來探索印記基因的表達調控。這将為我們提供一個很好的模型來研究表觀遺傳修飾與轉錄因子介導的基因轉錄調控之間的相關性和因果性，也将為我們在疾病與發育異常中矯正基因表達缺陷做鋪墊工作。

代表性論文：

1. Yue J#, Dai Q#, Hao S, Zhu S, Liu X, Tang Z, Li M, Fang H, Lin C*, Luo Z*. Suppression of the NTS-CPS1 regulatory axis by AFF1 in lung adenocarcinoma cells. J Biol Chem. 2021 Jan 22:100319. doi: 10.1016/j.jbc.2021.100319. Online ahead of print.

2. Du H#, Chen C#, Wang Y#, Yang Y, Che Z, Liu X, Meng S, Guo C, Xu M, Fang H, Wang F, Lin C*, Luo Z*. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. J Mol Cell Biol. 2021 Feb 15;12(11):894-905.

3. Guo C, Che Z, Yue J, Xie P, Hao S, Xie W, Luo Z*, Lin C*. ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation. Sci Adv. 2020 Apr 1;6(14):eaay4858. doi: 10.1126/sciadv.aay4858. eCollection 2020 Apr.

4. Luo Z#, Liu X, Xie H#, Wang Y, Lin C*. ZFP281 recruits MYC to active promoters in regulating transcriptional initiation and elongation. Mol Cell Biol. 2019 Sep 30. pii: MCB.00329-19. doi: 10.1128/MCB.00329-19.

5. Zhang Y, Wang C, Liu X, Yang Q, Ji H, Yang M, Xu M, Zhou Y, Xie W, Luo Z*, Lin C*. AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells. J Mol Cell Biol. 2018 Dec 7. doi: 10.1093/jmcb/mjy074.

6. Dai Q#, Shen Y#, Wang Y#, Wang X, Francisco JC, Luo Z, Lin C*. Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells. Nucleic Acids Res. 2017 Dec 1;45(21):12301-12310.

7.Francisco JC#, Dai Q#, Luo Z#, Wang Y, Chong RH, Tan YJ, Xie W, Lee GH, Lin C*. Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4.Mol Cell Biol. 2017 Sep 12;37(19). pii: e00040-17.

8.Wang Y#, Shen Y#, Dai Q, Yang Q, Zhang Y, Wang X, Xie W, Luo Z*, Lin C*. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron.Nucleic Acids Res. 2017 Feb 17;45(3):1177-1185.

9.Luo Z, Lin C*. Enhancer, epigenetics, and human disease.Curr Opin Genet Dev. 2016 Feb;36:27-33.

10. Luo Z*, Lin C, Woodfin AR, Bartom ET, Gao X, Smith ER, Shilatifard A*. Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity.Genes Dev. 2016 Jan 1;30(1):92-101.

11.Luo Z, Gao X, Lin C, Smith ER, Marshall SA, Swanson SK, Florens L, Washburn MP, Shilatifard A*. Zic2 is an enhancer-binding factor required for embryonic stem cell specification.Mol Cell. 2015 Feb 19;57(4):685-694.

12.Wijeweera A, Haj M, Feldman A, Pnueli L, Luo Z, Melamed P*. Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin.Biochim Biophys Acta. 2015 Mar;1849(3):328-41.

13.Lin C, Garruss AS, Luo Z, Guo F, Shilatifard A*. The RNA Pol II elongation factor Ell3 marks enhancers in ES cells and primes future gene activation.Cell. 2013 Jan 17;152(1-2):144-56.

14.Luo Z, Lin C, Shilatifard A*. The super elongation complex (SEC) family in transcriptional control.Nat Rev Mol Cell Biol. 2012 Sep;13(9):543-7.

15.Luo Z, Lin C, Guest E, Garrett AS, Mohaghegh N, Swanson S, Marshall S, Florens L, Washburn MP, Shilatifard A*. The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output.Mol Cell Biol. 2012 Jul;32(13):2608-17.

16.Luo Z, Wijeweera A, Oh Y, Liou YC, Melamed P*. Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription.Mol Cell Biol. 2010 Feb;30(3):745-63.