樊紅

發布者：許峰發布時間：2015-03-31浏覽次數：8814

樊紅簡曆

樊紅

教授，博士生導師

電話：

025-83272504

E-mail：

fanh@seu.edu.cn

Labweb：


辦公地點：

南京市丁家橋87号，bet356在线官方网站醫學院 綜合樓 北426房間


 個人簡介：

 醫學博士，教授，博導。bet356在线官方网站醫學院遺傳與發育生物學系，系主任。

 發育與疾病相關基因教育部重點實驗室腫瘤表遺傳研究課題組組長。

 江蘇省“青藍工程”中青年學術帶頭人

 中國抗癌協會腫瘤病因學專業委員會委員

 江蘇省遺傳學會副理事長

 江蘇省醫學會醫學遺傳學專業委員會委員、秘書

 南京抗癌協會第三屆理事會理事

 國家自然基金面上項目通信評議專家、教育部科技項目及獎勵評審通信評議專家


1990參加工作，2002,6畢業于哈爾濱醫科大學醫學遺傳學專業，獲醫學博士學位。2006.9–2006.12德國馬格德堡大學醫學院高級訪問學者。2008.3-2008.9香港大學醫學院Research Fellow。主要從事消化道腫瘤的表遺傳調控機制及腫瘤診斷學标志物，分子分型标志物的研究。先後承擔國家自然科學基金、江蘇省自然科學基金等各級别項目11項，現在研國家自然科學基金2項。參編國家級“十一五” 規劃教材《醫學遺傳學》，國家級“十二五”規劃教材《醫學遺傳學》。參編《腫瘤表觀遺傳學》《分子診斷技術》等專著。主講《普通遺傳學》《醫學遺傳學》《醫學細胞生物學》等課程。


主要研究方向：消化系統腫瘤的表觀遺傳現象與腫瘤表觀遺傳标志物的篩查與應用研究
表觀遺傳調控在功能基因表達中普遍存在，其表現形式多種多樣，以DNA甲基化修飾、組蛋白修飾及非編碼RNA（miRNA及lncRNA）調控為主，調控哺乳動物的基因的表達，參與細胞及機體的生命活動。惡性腫瘤是正常細胞的異常發育，存在多種表觀遺傳修飾及調控的異常。本研究組以消化系統腫瘤為研究對象，緻力于其發生及進展過程中表觀遺傳現象及機制的研究，力求發現在疾病過程中起重要作用關鍵分子和作用方式，指導于腫瘤的臨床診斷與治療。 近期關注分析消化道腫瘤中表觀遺傳調控因子及非編碼RNA 在消化道腫瘤中的作用及可能的機制，同時尋找并分析可以服務于臨床工作的表觀遺傳标志物及其應用的可能性，應用表觀遺傳調控因子SNP， 分析消化道腫瘤的遺傳易感性。


近10年課題組發表的主要科學研究論文：

  1. Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM, Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML*, Fan H*. HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling.Sci Rep. 2016;6:23521.

Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells.

  1. Fan H*, Zhao Z, Cheng Y, Cui H, Qiao F, Wang L, Hu J, Wu H, Song W. Tumour Biol. 2016 ;37:877-85

  2. Cui H, Zhao C, Gong P, Wang L, Wu H, Zhang K, Zhou R, Wang L, Zhang T, Zhong S,Fan H*. DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18(INK4C) in gastric carcinogenesis.  Sci Rep. 2015;5:13781.

  3. Zhao Z, Wang L, Song W, Cui H, Chen G, Qiao F, Hu J, Zhou R,Fan H*.Reduced miR-29a-3p expression is linked to the cell proliferation and cell migration in gastric cancer.World J Surg Oncol. 2015;13:101.

  4. Cui H, Wang L, Gong P, Zhao C, Zhang S, Zhang K, Zhou R, Zhao Z,Fan H*.Deregulation between miR-29b/c and DNMT3A Is Associated with Epigenetic Silencing of the CDH1 Gene, Affecting Cell Migration and Invasion in Gastric Cancer.PLoS One. 2015;10:e0123926.

  5. Wu HZ, Zhang K, Pihai Gong PH, Qiao FC, Wang L, Cui H, Sui XY, Gao JF, Fan H* A novel functional tagSNP rs7560488 in the DNMT3A1 promoter is associated with susceptibility to gastric cancer by modulating promoter activity.PLoS One. 2014；25：9:e92911

  6. Qiao F, Zhang K, Gong P, Wang L, Hu J, Lu S, Fan H*. Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.Mol Biol Rep. 2014 ;41:5693-700.

  7. Qiu XM, Zhang LH, Lu S, Song YW, Lao Y B, Hu JJ, Fan H* . Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation. Oncol Rep. 2014；31: 202-208

  8. Lao YB, Wu HZ, Zhao CC, Wu QY, Qiao FC,Fan H*. Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma. Biomedical Reports. 2013;1: 771-775.

  9. Zhao CC, Yan F, Wu HZ, Qiao FC, Qiu XM, Fan H*. DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma. Biomedical Reports. 2013;1:664-668.

  10. Qiu X, Dong S, Qiao F, Lu S, Song Y, Lao Y, Li Y, Zeng T, Hu J, Zhang L, Zhang L, Fan H*. HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma.Oncogene. 2013; 32, 3296 – 3305

  11. Wu Q, Lu S, Wang L, Hu J, Qiao F, Qiu X, Zhao C, Lao Y, Song Y, Fan H*. DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.Mol Biol Rep. 2012;39:10949-55.

  12. Fan H*, Chen L, Zhang F, Quan Y, Su X, Qiu X, Zhao Z, Kong KL, Dong S, Song Y, Chan TH, Guan XY. MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.Oncogene. 2012;31:2298-308.

  13. Qiao F, Su X, Qiu X, Qian D, Peng X, Chen H, Zhao Z, Fan H*. Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells.Oncol Rep. 2012;28:1475-81

  14. Zhao Z, Li C, Song Y, Wu Q, Qiao F, Fan H*. Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.Oncol Lett. 2012;3:450-454.

  15. Liu H, Jiao Y, Guan Y, Lao Y, Zhao C, Fan H*.The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer.Exp Ther Med. 2012;3:525-529.

  16. Zhao ZJ,Wu QX,Chen J, Qiu XM,Zhang JQ, Fan H*. Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cells. J Biomed Biotech. 2010;2010:737535.

  17. Fan H, Liu DS, Qiu XM, Qiao FC, Wu QX, Su XW, Zhang F, Song YW, Zhao ZJ, Xie W  A functional polymorphism in the DNA methyltransferase 3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.BMC Medicine. 2010 ；Feb 3;8:12

  18. Su XW, Lv CY, Qiao FC, Qiu XM, Huang WB, Wu QX, Zhao ZJ,Fan H. Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma. Oncol Rep.2010; 23:819-26.

  19. Hu J, Fan H*, Liu D, Zhang S, Zhang F, Xu H. DNMT3B promoter polymorphism and risk of gastric cancer.Dig Dis Sci.2010;55:1011-6.

  20. Qiu XM, Qiao FC, Su XW, Zhao ZJ, Fan H*. Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma. Exp. Ther. Med. 2010;1: 519-523.

  21. Fan H*, Zhao ZJ, Cheng J, Su XW, Wu QX, Shan YF. Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.World J Gastroenterol.2009；15:2020-6.

  22. Fan H*, Liu DS, Zhang SH, Hu JB, Zhang F, Zhao ZJ.The DNMT3B G>T promoter Polymorphism and the Risk of Esophagus Carcinoma in a Chinese Population.World J Gastroenterol. 2008;14:2230-4.

  23. Fan H*, Zhang F, Hu J, Liu D, Zhao Z. Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study. J Exp Clin Cancer Res. 2008; 27:24.

  24. Fan H*, Cheng J, Zhao ZJ.  Inhibition of de novo DNA Methyltransferase 3B is a Potential. Therapy for Hepatocellular Carcinoma. Gastroen Res. 2008;1:33-39

  25. Fan H*, Zhao Z, Quan Y,Xu J, Zhang J, Xie W.  DNA methyltransferase 1 knock down induces silenced CDH1 gene re-expression by demethylation of methylated CpG in HCC cell line SMMC-7721. Eur J Gastroenterol Hepatol. 2007;19:952-61  

  26. Fan H*, Zhao ZJ, Cheng YC, Shan YF, Lu ZH, Zhang JQ, Xie W. Analysis of gene induction and apoptosis in human hapetocellular carcinoma cells SMMC-7721 exposed to the methylation inhibitor 5-Aza-2’-deoxycytidine.  Chin Med J (Engl). 2007;120:1626-31

  27. Xu W, Fan H*, He X.LOI of IGF2 is associated with esophageal cancer and linked to methylation status of IGF2 DMR.J Exp Clin Cancer Res. 2006;25: 543-7.


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