張子超 教授 博士生導師
電話：025-83790939
Email：zhangzc@seu.edu.cn
個人簡介
1998-2002年，南京大學，生物化學專業，學士
2002-2005年，南京大學，生物化學與分子生物學，碩士
2005-2011年，美國得克薩斯州大學西南醫學中心，細胞調控專業，博士
2011-2012年，美國得克薩斯州大學西南醫學中心，藥理系，博士後
2012-2022年，bet356在线官方网站，生命科學研究院，副教授
2022年10月，bet356在线官方网站，教授
研究方向：
兒童智力發育遲緩和老年人群中的神經退行性疾病是常見多發的神經系統疾病，目前人們對其複雜的發病機理知之甚少，缺乏有效的治療手段，是生物醫學領域裡未解的難題。對神經發育，突觸形成和維持，神經遞質的傳遞和神經環路形成過程中關鍵分子及分子事件的研究是解開難題的核心。我們主要運用生物化學與分子生物學，細胞生物學，結構生物學，生物信息學和遺傳學等方法與手段，通過對細胞内蛋白質的表達調控，蛋白質之間的相互作用，蛋白質和RNA等生物大分子在細胞内的轉運以及相應細胞生理生化功能的研究，來揭示神經發育與退化過程的分子機制，探讨智力發育遲緩和神經退行性性疾病的發病機理，尋找新的治療手段。
代表性論文：
1. Zhang ZC, Han J. The First National Prevalence of Autism Spectrum Disorder in China. Neurosci Bull. 2020 Sep;36(9):959-960. doi: 10.1007/s12264-020-00571-x. Epub 2020 Aug 29. PubMed PMID: 32860208; PubMed Central PMCID: PMC7475156.
2. Gu Q, Wu J, Tian Y, Cheng S, Zhang ZC, Han J. Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. J Biol Chem. 2020 Apr 24;295(17):5554-5563. doi: 10.1074/jbc.RA120.012764. Epub 2020 Mar 20. PubMed PMID: 32198182; PubMed Central PMCID: PMC7186184.
3. Liu X, Dou LX, Han J, Zhang ZC. The Renpenning syndrome-associated protein PQBP1 facilitates the nuclear import of splicing factor TXNL4A through the karyopherin β2 receptor. J Biol Chem. 2020 Mar 27;295(13):4093-4100. doi: 10.1074/jbc.RA119.012214. Epub 2020 Feb 10. PubMed PMID: 32041777; PubMed Central PMCID: PMC7105315.
4. Mu Y, Tian Y, Zhang ZC, Han J. Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. J Biol Chem. 2019 Jul 19. pii: jbc.RA119.009602. doi: 10.1074/jbc.RA119.009602. [Epub ahead of print] PubMed [citation] PMID: 31324721
5. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 Apr 19;173(3):677-692.e20. doi: 10.1016/j.cell.2018.03.002. PubMed [citation] PMID: 29677512, PMCID: PMC5911940
6. Li Q, Li Y, Wang X, Qi J, Jin X, Tong H, Zhou Z, Zhang ZC, Han J. Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor. Curr Biol. 2017 Dec 4;27(23):3616-3625.e5. doi: 10.1016/j.cub.2017.10.052. Epub 2017 Nov 22. PubMed [citation] PMID: 29174887
7. Tian Y, Zhang ZC, Han J. Drosophila Studies on Autism Spectrum Disorders. Neurosci Bull. 2017 Dec;33(6):737-746. doi: 10.1007/s12264-017-0166-6. Epub 2017 Aug 9. Review. PubMed [citation] PMID: 28795356, PMCID: PMC5725381
8. Zhang XY, Qi J, Shen YQ, Liu X, Liu A, Zhou Z, Han J, Zhang ZC. Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Hum Mol Genet. 2017 Mar 1;26(5):955-968. doi: 10.1093/hmg/ddx010. PubMed [citation] PMID: 28073926
9. Tong H, Li Q, Zhang ZC, Li Y, Han J. Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep. 2016 Dec 1;6:38246. doi: 10.1038/srep38246. PubMed [citation] PMID: 27905548, PMCID: PMC5131284
10. Wei JH, Zhang ZC, Wynn RM, Seemann J. GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules. Cell. 2015 Jul 16;162(2):287-299. doi: 10.1016/j.cell.2015.06.014. Epub 2015 Jul 9. PubMed [citation] PMID: 26165940, PMCID: PMC4506739
11. Wan D, Zhang ZC, Zhang X, Li Q, Han J. X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs. Hum Mol Genet. 2015 Aug 15;24(16):4599-614. doi: 10.1093/hmg/ddv191. Epub 2015 May 22. PubMed [citation] PMID: 26002102
12. Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W, Han J. Drosophila neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci. 2013 Sep 25;33(39):15545-54. doi: 10.1523/JNEUROSCI.0819-13.2013. PubMed [citation] PMID: 24068821, PMCID: PMC6618453
13. Tian Y, Li T, Sun M, Wan D, Li Q, Li P, Zhang ZC, Han J, Xie W. Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron. 2013 Jan 23;77(2):311-22. doi: 10.1016/j.neuron.2012.11.012. PubMed [citation] PMID: 23352167
14. Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look AT. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 2013 Jan;27(1):66-74. doi: 10.1038/leu.2012.219. Epub 2012 Jul 31. PubMed [citation] PMID: 22847027, PMCID: PMC3542631
15. Zhang ZC, Chook YM. Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12017-21. doi: 10.1073/pnas.1207247109. Epub 2012 Jul 9. PubMed [citation] PMID: 22778397, PMCID: PMC3409756
16. Zhang ZC, Satterly N, Fontoura BM, Chook YM. Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Mol BiolCell. 2011 Dec;22(23):4657-68. doi: 10.1091/mbc.E11-03-0222. Epub 2011 Sep 30. PubMed [citation] PMID: 21965294, PMCID: PMC3226482
17. Qian F, Li YP, Sheng X, Zhang ZC, Song R, Dong W, Cao SX, Hua ZC, Xu Q. PRL-3 siRNA inhibits the metastasis of B16-BL6 mouse melanoma cells in vitro and in vivo. Mol Med. 2007 Mar-Apr;13(3-4):151-9. Erratum in: Mol Med. 2007 May-Jun;13(5-6):325. PubMed [citation] PMID: 17592549, PMCID: PMC1892759
18. Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM. Structure-based design of a pathway-specific nuclear import inhibitor. Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PubMed [citation] PMID: 17435768, PMCID: PMC3437620
19. Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang ZC, Chook YM. Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell. 2006 Aug 11;126(3):543-58. PubMed [citation] PMID: 16901787, PMCID: PMC3442361
20. Qian F, Zhang ZC, Wu XF, Li YP, Xu Q. Interaction between integrin alpha(5) and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1269-75. PubMed [citation] PMID: 15979576
