李默怡

發布者:吳志龍發布時間:2020-09-08浏覽次數:8334

   


 


李默怡     副教授、博士生導師                  

 電  話

 Email: limoyi@seu.edu.cn

辦公地點:李文正樓南204



個人簡介:

19969月 — 20006月    學士, 微生物專業,華中農業大學

20009月 — 20036月    碩士, 生化工程專業,華中科技大學

20038月 — 20085月    博士, 植物病理專業,佛羅裡達大學

20091月 — 20137月    博士後,佛羅裡達大學

20141月 — 20162月    博士後,bet356在线官方网站

20162月至今               副研究員,bet356在线官方网站


研究方向:

  1. 神經發育與退行性疾病的分子機理

  2. 環路發育及功能的遺傳控制機制


近期代表性論文:

  1. Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477. * co-first author; # Co-corresponding author

  2. Xing G*, Li M* (co-first author), Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W.  Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457

  3. Liang X, Liberti D, Li M, Kim YT, Hutchens A, Wilson R, Rollins JA. Oxaloacetate acetylhydrolase gene mutants of Sclerotinia sclerotiorum do not accumulate oxalic acid, but do produce limited lesions on host plants. (2015) Mol. Plant Pathol. 16: 559-571.

  4. Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322

  5. Lee KY*, Li M* (co-first author), Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900

  6. Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB and Swanson MS. Progressive impairment of muscle regeneration in muscleblind-like 3 Isoform knockout mice. (2013) Hum. Mol. Genet. 22: 3547-3558

  7. Warren SA, Briggs LE, Zeng H, Chuang J, Chang Eileen, Terada R, Li M, Swanson MS, Wood CE, Spinale FG, Maupine-Furlow J, McMullen JR, Moss R, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. (2012) Circulation. 126: 2575-2588  

  8. Li M, Liang X, and Rollins JA. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420

  9. Li M and Rollins JA. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538

  10. Li M and Rollins JA. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43




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