報告題目：Gene expression regulation by RNA Methylation
報告人： 楊運桂 特聘研究員
中國科學院
1995年學士畢業于複旦大學生命科學學院；2000年博士畢業于中國科學院上海藥物研究所； 2000年國際癌症研究署博士後/Staff Scientist; 2005年英國癌症研究署博士後；2008年中國科學院北京基因組研究所研究員。
研發RNA化學修飾測序和分析技術，研究RNA甲基化特征及其修飾酶，闡明其功能及人類疾病關聯的調控機制。參與發現 RNA甲基轉移酶和去甲基酶，證明 RNA甲基化的動态可逆性，揭示其調控基因剪接和出核等新機制，及RNA甲基化調控幹細胞定向分化和組織器官發育等重要作用。
報告摘要：Over 100 types of chemical modifications have been identified in various types of RNAs including non-coding RNA and mRNA, among which methylation is the most common modification. The N6- methyl-adenosine (m6A) and N5-methyl-cytosine (m5C) are the most common and abundant internal modifications on mRNA molecules. The recent identification of methyltransferases METTL3/METTL14/WTAP and NSUN2, and m6A demethylases ALKBH5 and FTO, supports the reversibility of RNA methylation. Several YTH-domain-containing proteins YTHDF1-3 and YTHDC1-2 specifically binding to m6A and ALYREF recognizing m5C have been identified to regulate various mRNA processing, suggesting vital roles of RNA modifications in gene expression control. Our recent works revealed indispensable roles of m6A in mRNA translation, spermatogonial differentiation, and haematopoietic stem and progenitor cell specification, and 5-methylcytosine promotes mRNA export. We have further performed RNA-BisSeq to map transcriptomic profiles of m5C in early embryos of Zebra fish and human cancers. We will discuss the recent progress in RNA modifications and their potential biological significance in this seminar.
報告時間：2019年9月17号上午10:00
報告地點：李文正南樓213會議室
主持人： 林承棋 教授
