邢廣林 教授江蘇特聘教授博士生導師
E-mail: guanglinxing@seu.edu.cn
辦公地點：bet356在线官方网站四牌樓校區五五樓342
個人簡介：
本科畢業于安徽師範大學，博士畢業于bet356在线官方网站，随後于美國奧古斯塔大學、凱斯西儲大學作博士後研究。2022年2月入職bet356在线官方网站，擔任教授。獲國家自然科學基金面上項目、江蘇特聘教授特别支持項目、南京市留學人員科技創新項目等資助。
研究方向：
突觸是神經元與靶細胞之間形成的特殊連接，介導神經信号傳遞，在神經環路形成、腦功能行使中扮演重要作用。突觸結構或功能異常可導緻精神疾病、運動障礙等問題。本課題組利用小鼠等模式生物，以神經肌肉接頭（運動神經元與肌肉之間形成的突觸）為研究對象，綜合運用細胞生物學、分子生物學、電生理等手段，揭示突觸形成、成熟調控機制，并探究運動神經元退行性疾病——肌萎縮性側束硬化症（也被稱為漸凍症）的發病機制和治療策略。
代表性論文：
1)Guanglin Xing, Hongyang Jing, Zheng Yu, Peng Chen, Hongsheng Wang, Wen-Cheng Xiong*, and Lin Mei*. Membraneless condensates by rapsyn phase separation as a platform for neuromuscular junction formation. Neuron, 2021, https://doi.org/10.1016/j.neuron.2021.04.021, Cover Story, Volume 109, Issue 12.
2)Guanglin Xing, Wen-Cheng Xiong, and Lin Mei*. (2020). Rapsyn as a signaling and scaffolding molecule in NMJ formation and maintenance. Neuroscience Letters, 135013. doi.org/10.1016/j.neulet.2020.135013, Review.
3)Guanglin Xing#, Hongyang Jing#, Lei Zhang, Yu Cao, Lei Li, Kai Zhao, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, and Lin Mei* (2019). A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 2019; 8: e49180 DOI: 10.7554/eLife. 49180.
4)Guanglin Xing#, Moyi Li#, Yichen Sun, Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction. eLife 2018; 7: e30457 DOI: 10.7554/eLife.30457.
5)Guanglin Xing#, Guangming Gan#, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, unhai Han, and Wei Xie*. (2014). Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation. The Journal of Biological Chemistry 289, 31867-31877; a paper of the week.
6)Zhibing Tan#, Heath L. Robinson#, Dong-Min Yin, Yu Liu, Fang Liu, Hongsheng Wang, Thiri W. Lin, Guanglin Xing, Lin Gan, Wen-Cheng Xiong, and Lin Mei* (2018). Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 98, 380-393 e384.
7)Lei Li#, Yu Cao#, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chenyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, and Lin Mei*. (2016). Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron 92, 1007-1019.
8)Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangmin Gan, David Knight, Sheila lrene With, He Cui, Han, Junhai Han, Xiankun Zeng, Ming Fang, Gabeielle L. Boulianne, and Wei Xie*. (2011). Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. The Journal of Neuroscience, 31, 687-699.
