方可

發布者：吳志龍發布時間：2022-11-16浏覽次數：2079


方可 講師 碩士生導師

  

E-mail: kfang@seu.edu.cn

辦公地點：李文正樓北235

 

個人簡介：

2012年和2018年于中山大學生命科學學院獲得學士和博士學位，2018-2021年于中山大學生命科學學院進行博士後研究。2021年9月加入bet356在线官方网站，任講師，碩士生導師。共發表SCI論文18篇，其中13篇IF>10。主持國家自然基金青年項目，博士後面上項目等項目，獲得江蘇省雙創博士，bet356在线官方网站至善青年學者等榮譽稱号。

 

研究方向：轉錄調控在細胞死亡及疾病中的機制和功能

  1. 轉錄調控在細胞死亡中的作用機理

       目前，已經十幾種不同的細胞死亡途徑被鑒定，每一條途徑都受不同基因通路的調控，可謂“千亡千面”。作為基因表達的起始調控，轉錄調控在其中扮演什麼作用？我們運用多組學分析，分子生物學，細胞生物學，小鼠模型等多種研究手段聚焦不同死亡途徑的轉錄調控研究。

  2. 轉錄調控在疾病中的功能機制及靶向治療

       癌基因，抑癌基因等的轉錄調控異常往往直接介導的癌症産生。我們聚焦于癌症相關基因的轉錄調控，尋找癌症發生發展的重要調控因子，并以此為基礎開發潛在的靶向治療策略。  

     

代表性論文（*第一作者；#通訊作者）：

  1. Zhao XR*, Fang K*, Liu XX*, Yao RH, Wang M, Li FF, Hao SH, He JJ, Wang Y, Fan MH, Huang W, Li YP, Gao C, Lin CQ and Luo ZJ. QSER1 preserves the suppressive status of the pro-apoptotic genes to prevent apoptosis. Cell Death and Differentiation 2022. Nov 12. doi: 10.1038/s41418-022-01085-x.

  2. Huang W, Zeng ZC, Wang WT, Sun YM, Chen YQ, Luo XQ, Fang K#. A CRISPR/CAS9-based strategy targets the personalized chimeric neosequence in fusion-driven cancer genome for precision medicine. Clinical and Translational Medicine 2021, 11(3): e355.

  3. Fang K*, Huang W*, Sun YM, Chen TQ, Zeng ZC, Yang QQ, Pan Q, Han C, Sun LY, Luo XQ, Wang WT, Chen YQ. Cis-acting lnc-eRNA SEELA directly binds histone H4 to promote histone recognition and leukemia progression. Genome Biology 2020, 21(1): 269.

  4. Huang W*, Fang K*, Chen TQ, Zeng ZC, Sun YM, Han C, Sun LY, Chen ZH, Yang QQ, Pan Q, Luo XQ, Wang WT, Chen YQ. circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression. Journal of Hematology＆Oncology 2019, 12(1): 103.

  5. Fang K*, Han BW*, Chen ZH, Lin KY, Zeng CW, Li XJ, Li JH, Luo XQ, Chen YQ. A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target. Human Molecular Genetics 2014, 23(12): 3278-3288.

  6. Fang K, Qian F, Chen YQ. MicroRNAs as regulators in normal hematopoietic and leukemia stem cells: current concepts and clinical implications. Current Molecular Medicine2012 Jun,12(5):536-46.

  7. Huang W, Sun YM, Pan Q, Fang K, Chen XT, Zeng ZC, Chen TQ, Zhu SX, Huang LB, Luo XQ, Wang WT and Chen YQ: The snoRNA-like lncRNA LNC-SNO49AB drives leukemia by activating the RNA-editing enzyme ADAR1. Cell Discovery 2022, 8(1): 117.

  8. Han C, Sun LY, Luo XQ, Pan Q, Sun YM, Zeng ZC, Chen TQ, Huang W, Fang K, Wang WT, Chen YQ. Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex. Cell Reports 2022, 38(13): 110421.

  9. Huang W, Chen TQ, Fang K, Zeng ZC, Ye H, Chen YQ. N6-methyladenosine methyltransferases: functions, regulation, and clinical potential. Journal of Hematology＆Oncology 2021, 14(1): 117.

  10. Sun L, Wang W, Han C, Huang W, Sun Y, Fang K, Zeng Z, Yang Q, Pan Q, Chen T, Luo X, Chen Y. The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation. Molecular Cell 2021, 81(21): 4493-4508.

  11. Sun YM, Wang WT, Zeng ZC, Chen TQ, Han C, Pan Q, Huang W, Fang K, Sun LY, Zhou YF, Luo XQ, Luo C, Du X, Chen YQ. circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression. Blood 2019, 134(18): 1533-1546.

  12. Wang WT, Han C, Sun YM, Chen ZH, Fang K, Huang W, Sun LY, Zeng ZC, Luo XQ, Chen YQ. Activation of the Lysosome-Associated Membrane Protein LAMP5 by DOT1L Serves as a Bodyguard for MLL Fusion Oncoproteins to Evade Degradation in Leukemia.Clinical Cancer Research 2019, 25(9): 2795-2808.

  13. Huang W, Wang WT, Fang K, Chen ZH, Sun YM, Han C, Sun LY, Luo XQ, Chen YQ. MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47. Molecular Cancer 2018, 17(1):

  14. Chen ZH, Wang WT, Huang W, Fang K, Sun YM, Liu SR, Luo XQ, Chen YQ. The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway. Cell Death and Differentiation 2017, 24(2): 212-224.

  15. Duan FT, Qian F, Fang K, Lin KY, Wang WT, Chen YQ. miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. Molecular Cancer 2013, 12: 164.

     

 

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