謝維

發布者:許峰發布時間:2019-08-21浏覽次數:43625




謝 維

教授、博士生導師
“發育與疾病相關基因”教育部重點實驗室 主任
電話:025-83790970
E-mail:wei.xie@seu.edu.cn
Labweb: 
辦公地點:南京市四牌樓2号,李文正樓北221
  

個人簡介:

   19817月參加工作,19916月畢業于南京鐵道醫學院微生物學與免疫學專業,獲碩士學位;199510月畢業于南京大學生物化學與分子生物學系,獲博士學位。19971月至199812月在美國羅切斯特大學醫學中心作博士後;19995月至20018月在加拿大多倫多大學附屬多倫多病童醫院博士後、訪問學者。20019月作為教育部“CJ學者獎勵計劃特聘教授,受聘為bet356在线官方网站基礎醫學院遺傳學研究中心主任,博士生導師;2003年獲準建設發育與疾病相關基因教育部重點實驗室,任主任;20044月至200911月任bet356在线官方网站基礎醫學院院長,200912月至201912月,任bet356在线官方网站生命科學研究院院長。先後獲得國家自然科學基金(面上、重點)、國家傑出青年科學基金、美國NIH基金(RO3)、國家“973”重大基礎研究項目等資助。

研究方向:突觸發育調控與認知疾病機制

   大腦通過約1015個突觸連接而成的巨大通訊網絡來進行信息處理、行使功能。突觸通過自身的可塑性,傳遞、轉變和完善信号。突觸細胞粘附因子,通過連接突觸前、後細胞,調節突觸傳遞信号,并且通過形成特異性的突觸功能來決定神經網絡的特性。家系分析發現,人類突觸細胞粘附因子基因發生突變與孤獨症、精神分裂症等關聯;基因組水平研究顯示,包括孤獨症、精神分裂症等多種認知性疾病,均存在編碼突觸分子,如CaherinsProtocadherinsL1CAMNeuroliginNeurexinCNTNAP2Contactins等的基因異常,但其緻病機制不清。本研究組以神經元表面蛋白分子為研究對象,應用綜合研究手段,結合模式生物,探索突觸發生、成熟、環路形成以及在學習記憶等高級神經活動與行為中的作用,探讨其在遺傳和表觀遺傳水平上的調控機制,為闡明其在相關的認知障礙與疾病中的作用奠定基礎。

本課題組日常負責人聯系方式:

呂卉卉:025-83790976 


近期代表性論文:


  1.  Moyi Li*, Yan Zhuang, Ranjan Batra, James D. Thomas, Mao Li, Curtis A Nutter, Marina M. Scotti, Helmut A Carter, Zhan Jun Wang, Xu Sheng Huang, Chuan Qiang Pu, Maurice S. Swanson, Wei Xie *. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proceedings of the National Academy of Sciences of the United States of America, 2020,117(10): 5472-5477.

  2.  Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie *. Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA. Molecular Therapy - Methods & Clinical Development, 2020, 17:401-408.

  3.  Rui Mao, Rui Deng, Yan Wei, Lifang Han, Yanghong Meng, Wei Xie*, Zhengping Jia*. LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration. Mol Brain, 2019, 12(1):67.

  4. Guanglin Xing, Moyi Li, Menglong Rui, Nana Tao, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. Neuroligin 1 Regulates Postsynaptic Actin Cytoskeleton via WAVE Regulatory Complex in Drosophila Neuromuscular Junction, eLife, 2018, 7:e30457.

  5. Jun Wu, Yao Tian, Guanglin Xing, Nana Tao, Huihui Lv, Junhai Han, Chengqi Lin and Wei Xie*. Proteolytic Maturation of Drosophila Neuroligin 3 by Tumor Necrosis Factor α-converting Enzyme in the Nervous System. Biochimica et Biophysica Acta(BBA) - General Subjects, 2018, 1862(3):440-450

  6. Xinwang Zhang, Menglong Rui, Guangming Gan, Cong Huang, Jukang Yi, Huihui Lv, Junhai Han, and Wei Xie*. Presynaptic Neuroligin 4 Positively Regulate Neuromuscular Synaptic Growth in Drosophila via BMP Signaling Pathway. The Journal of Biological Chemistry, 2017, 292(44):17991-18005.

  7. Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia, Wei Xie*. The neuronal protein neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for presynaptic vesicle clustering. The Journal of Biological Chemistry, 2017, 292(35):14334-14348

  8. Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie*. Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila. Journal of Molecular Cell Biology, 2017, 9(3):231-242

  9. An Liu, Zikai Zhou, Rui Dang, Guiqing He, Celeste Leung, Daniel Pak, Zhengping Jia*, Wei Xie*. Neuroligin-1 regulates spines and synaptic plasticity via LIMK1/cofilin mediated actin reorganization. The Journal of Cell Biology, 2016, 212(4):449-463 (Cover Story, COMMENT:Karen A. NewellLitwa. Breaking down to build up: Neuroligin’s C-terminal domain strengthens the synapse. J. Cell Biol. 212, 375-377)

  10. Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Maria Morena, Matthew N. Hill*, Wei Xie*, Zhengping Jia*. p21-Activated Kinase 1 Restricts Tonic Endocannabinoid Signaling in the Hippocampus. eLife, 2016, 5:e14653.

  11. Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie*, Zhengping Jia*. PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Molecular Brain, 2015, 8:36

  12. Guanglin Xing, Guangming Gan, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, Junhai Han, Wei Xie*. Drosophila Neuroligin3 Regulates Neuromuscular Junction Development and Synaptic Differentiation. The Journal of Biological Chemistry, 2014, 289(46):31867-31877 (Papers of the Week)

  13. Yi Li, Zikai Zhou, Xinwang Zhang, Huawei Tong, Peipei Li, Zichao Zhang, Zhengping Jia, Wei Xie* and Junhai Han*. Drosophila Neuroligin4 regulates sleep through modulating GABA transmission. The Journal of Neuroscience, 2013, 33(39):15545-15554

  14. Yao Tian, Yi Li, Mingkuan Sun, Wen Hu, Didi Wan, Jing Li, Junhai Han* and Wei Xie*. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron, 2013, 77(2):311-322.

  15. Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne*, Wei Xie*. Neuroligin2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. The Journal of Neuroscience, 2011, 31(2):687-699 (This Week in The Journal)
















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