課題組長：
柴人傑，bet356在线官方网站生命健康高等研究、beat365体育官网平台
Renjie Chai Ph.D., School of Life Science and Technology,
Southeast University, Nanjing, China
研究領域：神經幹細胞和内耳幹細胞的轉錄調控機制；
聽覺神經元和毛細胞再生。
地址：南京市玄武區四牌樓2号，bet356在线官方网站李文正樓北231室，210096
研究組長簡介：
柴人傑，1982年11月出生，bet356在线官方网站首席教授、二級教授，bet356在线官方网站生命健康高等研究院執行院長、beat365体育官网平台副院長。2004年本科畢業于中國科學技術大學，生物科學專業，導師施蘊渝院士。2009年博士畢業于美國Baylor大學，生物醫學專業，導師丁家桓教授，博士期間獲貝勒大學第六屆學生研究成果讨論會優秀研究成果獎。2009年至2013年于Stanford大學醫學院從事博士後工作，博士後期間作為項目負責人主持的課題獲美國斯坦福大學醫學院院長獎勵基金和美國聽覺健康基金會資助。2013年8月開始在bet356在线官方网站任教授，博士生導師。現任中國生物物理學會聽覺、言語與交流分會會長；中國生理學會幹細胞生理專業委員會副主委、候任主委；中國細胞生物學學會發育生物學分會副會長；中國生物醫學工程學會幹細胞工程技術分會副會長；中國聽力醫學發展基金會基礎研究專家委員會主委和專家指導委員會常務委員；國際耳内科醫師協會執委（Executive board member）；中國醫促會耳内科分會副主委聽覺基礎研究學組組長；中國生物醫藥産業鍊創新與轉化聯盟醫療器械分會會長；中國老年醫學學會理事，耳科學分會常務委員；國家耳鼻咽喉疾病臨床醫學研究中心學術指導委員會委員；中國細胞生物學會青委會委員，幹細胞分會委員；江蘇省醫學會聽力學分會副會長；江蘇省人才創新創業促進會副秘書長，常務理事；江蘇省研究型醫院學會青年科學家分會會長；江蘇省發育生物學會常務理事和聽覺科學專委會主委；江蘇省雙創聯合會常務理事和生物醫藥專委會副秘書長；江蘇省僑聯僑界專家委員會常務委員（特聘專家）；江蘇省防聾治聾技術指導專家組委員。現任ESCI期刊American Journal of Stem Cells(AJSC) 執行主編 (Executive Editor-in-Chief)，Frontiers in Cell and Developmental Biology、Neuroscience Bulletin、實用醫院臨床雜志副主編（Associate Editor），Fundamental Research，American Journal of Translational Research（AJTR），Fundamental Research，Hearing Research，Frontiers of Medicine，Global Journal of Otolaryngology，Engineering，Annals of Translational Medicine和Journal of Otorhinolaryngology, Hearing and Balance Medicine（OHBM）期刊編委(Editorial Board Member)，Neural Plasticity 和Journal of Bio-X期刊Lead Guest Editor。
先後作為項目或課題負責人主持科技部國家重點研發計劃幹細胞及轉化研究重點專項，科技部青年973計劃，中國科學院“器官重建與制造”A類戰略性先導科技專項，國家自然科學基金委重點項目1項，重大集成項目1項，面上項目2項，江蘇省重點研發計劃社會發展項目，四川省科技計劃重點研發項目，人力資源和社會保障部留學人員科技活動重點項目，教育部留學人員項目，全球二十強藥企德國Boehringer Ingelheim 公司的500萬元的Faculty Research Award和瑞士Novartis公司70萬元Faculty Research Award等15項課題。相關工作發表在Cell, Nature communications, Science Advances, PNAS，Autophagy, Advanced Materials, Advanced Science, Advanced Functional Materials，Biomaterials, Biosensors and Bioelectronics，ACS Applied Materials & Interfaces,Redox Biology, Antioxidants & Redox Signaling, Development，Cellular and Molecular Life Sciences, Cell Death & Disease等有國際影響力的學術期刊上，近5年發表通訊作者SCI論文130篇（總影響因子1246.38，平均影響因子9.33，其中IF>30分4篇，IF 10-30分37篇），其中4篇論文被Faculty1000列為推薦文章，1篇論文入選Cell正刊年度最佳論文，13篇論文入選了ESI高被引論文，2篇論文入選熱點論文，總他引6000餘次，h-index 48；作為主編出版2本中文耳鼻喉學科教材和一本英文專著,作為編者參編了韓濟生院士主編的第四版神經科學教材，負責第六篇第四章聽覺系統的撰寫；研究成果也獲得了第三屆全國創新争先獎狀，教育部霍英東教育基金會高等院校青年科學獎一等獎（第一完成人），中國青年科技獎（第一完成人），中華醫學科技獎二等獎（第一完成人），江蘇省青年科技獎（第一完成人），樹蘭醫學青年獎（第一完成人），高等學校科學技術獎自然科學一等獎（第三完成人），江蘇省醫學科技獎一等獎（第二完成人），湖北省科學技術獎二等獎（第二完成人）和上海市技術發明一等獎（第九完成人），也獲得了2022年度中國科協十大強國青年科學家，2020年度江蘇省十大青年科技之星，江蘇省五四青年獎章提名獎；申報了23項國家發明專利，授權了5項國家發明專利1項實用新型專利；另有國際會議大會發言8次，國際會議論文21篇，作為大會主席參與舉辦了三屆中國聽覺科學大會（第1,3,4屆），作為分論壇主席主持了一屆國際耳内科醫師學會年會聽覺異常與平衡障礙分論壇（第19屆），主持了兩屆中國生物物理學會年會聽覺研究分論壇（第15,16屆），主持了兩屆中國神經科學學會年會聽覺研究分論壇（第12，13屆）。
研究内容：長期緻力于内耳毛細胞和神經元的再生和保護以及神經幹細胞和内耳幹細胞的轉錄調控機制的研究。主要研究内容包括：1.系統的研究了多種信号通路對于内耳幹細胞和神經幹細胞增殖和分化的轉錄調控機制；2.結合多基因協同調控，生物材料和電刺激，磁刺激等物理調控因素有效促進神經元和毛細胞的再生和聽覺功能的部分重建；3通過調控免疫系統，自噬，線粒體功能和氧化應激有效的保護了噪音和藥物導緻的毛細胞損傷和聽力損失。
代表性論著
專著：
1. 高下（主編），錢曉雲（主編），柴人傑（主編），管瑩（主編），人工耳蝸植入暨感音神經性耳聾醫療手冊，bet356在线官方网站出版社，196千字，ISBN 978-7-5641-8304-2，2020
2. Huawei Li (Editor), Renjie Chai（Editor）. Hearing Loss: Mechanisms, Prevention and Cure. Springer Nature, ISSN 0065-2598 ISSN 2214-8019 (electronic),Springer Nature 出版社,ISBN 978-981-13-6122-7 ISBN 978-981-13-6123-4 (eBook), Online Link: https://doi.org/10.1007/978-981-13-6123-4, Library of Congress Control Number: 2019933567，2019.
3. 柴人傑（主編），陳峰，陳傑，戴豔紅，高下（主編），陸玲，麻曉峰，王俊國，錢曉雲，楊烨，俞晨傑，張莎莎，周函，朱光潔，人工聽覺技術概要，南京大學出版社, 352千字，ISBN 978-7-305-17890-0，2016
代表性期刊論文：
1. Jie Zhao#, Hong Fu#, Jingjing Yu#, Weiqi Hong#, Xiaowen Tian#, Jieyu Qi#, Suyue Sun, Chang Zhao, ChaoWu, Zheng Xu, Lin Cheng, Renjie Chai*(并列通訊作者）, Wei Yan*, Xiawei Wei*, Zhenhua Shao*. Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nature Communications, 14(1):962, 2023 (IF:17.694)
2. Hong Chen#, Hui Zhang#, Yanhong Dai#, Haofang Zhu, Guodong Hong, Chengwen Zhu,Xiaoyun Qian*, Renjie Chai*(并列通訊作者）, Xia Gao*, and Yuanjin Zhao*. Magnetic Hydrogel Microrobots Delivery System forDeafness Prevention. Advanced Functional Materials, 2303011, 2023(IF:19.924)
3. Yuhua Zhang#, Qiaojun Fang#, Hongfeng Wang#, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng , Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang*, Xia Gao*, Zheng Ying*, Renjie Chai*（最後并列通訊作者）.Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy, 19(1):75-91, 2023 (IF:13.391)
4. Dong Liu#, Chun-hui Liang#, Bin Huang#, Xiao Zhuang#, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin*, Renjie Chai*(并列通訊作者）, Bo Chu*. Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumour growth. Advanced Science, e2204006, 2023 (IF:17.521)
5. Guodong Hong#, Xiaolong Fu#,*, Xin Chen#, Liyan Zhang#, Xuan Han, Shuqin Ding, Ziyi Liu, Liuli Bi, Wen Li, Miao Chang, Ruifeng Qiao, Siwei Guo, Hailong Tu, Renjie Chai*（最後并列通訊作者）. Dyslexia-related hearing loss occurs mainly through the abnormal spontaneous electrical activity of spiral ganglion neurons. Advanced Science, e2205754, 2023 (IF:17.521)
6. Xiaolong Fu#,*, Peifeng Wan#, Ling Lu#, Yingcui Wan, Ziyi Liu, Guodong Hong, Shengda Cao, Xiuli Bi, Jing Zhou, Ruifeng Qiao, Siwei Guo, Yu Xiao, Bingzheng Wang, Miao Chang, Wen Li, Peipei Li, Aizhen Zhang, Jin Sun, Renjie Chai*(并列通訊作者）, Jiangang Gao*. Peroxisome deficiency in cochlear hair cells causes hearing loss by deregulating BK channels. Advanced Science, e2300402, 2023 (IF:17.521)
7. Guoqiang Sun#, Yandong Zheng#, Xiaolong Fu#, Weiqi Zhang#, Jie Ren#,Shuai Ma, Shuhui Sun, Xiaojuan He, Qiaoran Wang, Zhejun Ji, FangCheng, Kaowen Yan, Ziyi Liu, Juan Carlos Izpisua Belmonte, Jing Qu*, SiWang*, Renjie Chai*（并列通訊作者）,Guanghui Liu*. Single-cell transcriptomic Atlas of mouse cochlear aging. Protein & Cell,14(3):180-201, 2023(IF:15.328)
8. Hui Zhang, Huan Wang, Baojie Wen, Ling Lu, Yuanjin Zhao*, Renjie Chai*（最後并列通訊作者）. Ultrasound-responsive composited conductive silk conduits for peripheral nerve regeneration. Small Structures, 2300045, 2023 (IF: 11.343)
9. Lin Shi#, Guodong Hong#, Chuntao Chen*, Xueqian Li, Heng Zhang, Renjie Chai*(并列通訊作者), Dongping Sun*. Growth of spiral ganglion neurons induced by graphene oxide/oxidized bacterial cellulose composite hydrogel. Carbohydrate Polymers,311:120749, 2023 (IF：10.723）
10. Liyan Zhang#, Yuan Fang#, Fangzhi Tan#, Fangfang Guo#, Ziyu Zhang, Nianci Li, Qiuhan Sun, Jieyu Qi*, Renjie Chai*（最後并列通訊作者）. AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea. Cellular and Molecular Life Sciences, 80(4):86, 2023. (IF: 9.234)
11. Changling Xu#, Jieyu Qi#,*, Xiaojie Hu#, Liyan Zhang#, Qiuhan Sun, Nianci Li, Xin Chen, Fangfang Guo, Peina Wu*, Yi Shi*, Renjie Chai*（最後并列通訊作者）. Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. Cell Proliferation, e13458, 2023. (IF: 8.755)
12. Xuechun Yang#, Jieyu Qi#, Liyan Zhang#, Fangzhi Tan#,Hongming Huang, Chunlai Xu, Yong Cui*, Renjie Chai*(并列通訊作者), Peina Wu*. The role of Espin in the stereocilia regeneration and protection in Atoh1‐overexpressed cochlear epithelium. Cell Proliferation, e13483, 2023. (IF: 8.755)
13. Mingyu Xia#, Jiaoyao Ma#, Mingxuan Wu, Luo Guo, Yan Chen, GengLin Li, Shan Sun, Renjie Chai*（并列通訊作者）, Huawei Li*, Wenyan Li*. Generation of innervated cochlear organoid recapitulates early development of auditory unit. Stem Cell Reports, 18(1):319-336, 2023(IF:7.294)
14. Yuan Zhang#, Xiaolong Fu#*, Yiyuan Li#, Wen Li , Guodong Hong, Siwei Guo, Yu Xiao, Ziyi Liu, Shuqin Ding, Xiuli Bi, Fanglei Ye*, Jin Jin*, Renjie Chai*（最後并列通訊作者）.Macrophage-mediated immune response aggravates hearing disfunction caused by the disorder of mitochondrial dynamics in cochlear hair cells.Human Molecular Genetics, 32(7):1137-1151, 2023(IF:5.121)
15. Yangnan Hu#, Han Zhang#, Hao Wei#, Menghui Liao, Xiaoyan Chen, Jiayue Xing, Lian Duan, Cuntu Cheng, Weicheng Lu, Xuechun Yang, Peina Wu*, Huan Wang*, Jingdun Xie*, Renjie Chai*（最後并列通訊作者）. Conductive PS inverse opals for regulating proliferation and differentiation of neural stem cells. Engineered Regeneration, 4(2),214-221, 2023 (IF：0)
16. Guodong Hong#, Xiaolong Fu#, Jieyu Qi#, Buwei Shao#, Xuan Han, Yuan Fang, Shuang Liu, Cheng Cheng,Chengwen Zhu, Junyan Gao, Xia Gao, Jie Chen*, Ming Xia*, Wei Xiong*, Renjie Chai*（最後并列通訊作者）.Dock4 Is Required for the Maintenance of Cochlear Hair Cells and Hearing Function. Fundamental Research, 11:40,559-573, 2023(IF:0)
17. Lin Xia#, Xiaolong Zhao#, Xiangyu Ma#, Yangnan Hu, Yuan Zhang, Siyu Li, Jie Wang*, Yuanjin Zhao*, Renjie Chai*（最後并列通訊作者）. Controllable growth of spiral ganglion neurons by magnetic colloidal nanochains. Nano Today, 44:101507, 2022(IF:18.962)
18. Yong Tao#, Xiaoyi Liu#, Liu Yang#, Cenfeng Chu, Fangzhi Tan, Zehua Yu, Junzi Ke, Xiang Li, Xiaofei Zheng, Xingle Zhao, Jieyu Qi, Chao-Po Lin, Renjie Chai*(并列通訊作者), Guisheng Zhong*, Hao Wu*. AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration. Signal Transduction and Targeted Therapy, 7(1):109, 2022(IF:38.104)
19. Xiaolong Fu, Peipei Li, Linqing Zhang,Yuning Song，Yachun An，Aizhen Zhang，Wenwen Liu，Chao Ye, Yuan Zhang, Rongyu Yue, Xiaoyang Sun, Renjie Chai*(并列通訊作者), Haibo Wang*,Jiangang Gao*. Activation of Rictor/mTORC2 signaling acts as a new pivotal strategy to protect against sensorineural hearing loss. PNAS, 119(10):e2107357119, 2022(IF:12.779)
20. Lingna Guo#, Wenxuan Dai#, Zhengrong Xu#, Qiaoyi Liang, Eliot T. Miller, Shengju Li, Xia Gao, Maude W. Baldwin, Renjie Chai*（并列通訊作者）, and Qian Li*.Evolution of brain-expressed biogenic amine receptors into olfactory trace amine-associated receptors. Molecular Biology and Evolution, 39(3):msac006,2022(IF:8.8)
21. Zhong Zhang#, Gao Shan#, Yangnan Hu#,Xin Chen, Cheng Cheng, Xiaolong Fu, Shasha Zhang, Xinlin Wang, Yuwei Che, Chen Zhang, Renjie Chai*（唯一通訊作者）.Ti3C2TxMXene Composite 3D Hydrogel Potentiates mTOR signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids. Advanced Science, e2203557, 2022 (IF:17.521)
22. Shuai Wang#, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai*（并列通訊作者）, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science, 9(4):e2104789, 2022 (IF:17.521)
23. Lijun Cai, Cheng Zhao, Hanxu Chen, Lu Fan, Yuanjin Zhao*, Xiaoyun Qian*, Renjie Chai*（最後并列通訊作者）. Suction-cup-inspired adhesive micromotors for drug delivery. Advanced Science,9(1):e2103384, 2022 (IF:17.521)
24. Yangnan Hu#, Zhuoyue Chen#, Hongyang Wang#,Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu*, Yuanjin Zhao*, Renjie Chai*（最後并列通訊作者）.Conductive Nerve Guidance Conduits Based on Morpho Butterfly Wings for Peripheral Nerve Repair. ACS Nano, doi:10.1021/acsnano.1c11627, 2022(IF:18.027) （科技部網站推薦論文）
25. Menghui Liao#, Yangnan Hu#, Yuhua Zhang, Kaichen Wang, Qiaojun Fang, Yanru Qi, Yingbo Shen, Hong Cheng, Xiaolong Fu, Mingliang Tang*, Shan Sun*, Xia Gao*,Renjie Chai*（最後并列通訊作者）.3D Ti3C2Tx MXene-matrigel with electroacoustic stimulation to promote the growth of spiral ganglion neurons. ACS Nano, DOI:10.1021/acsnano.2c06306, 2022(IF:18.027) （國家自然科學基金委推薦論文）
26. Shuai Wang#,Chen Tao#,Huilin Mao,Linghui Hou,Yao Wang,Tao Qi,Yuan Yang,Sang-Ging Ong,Shijun Hu*,Renjie Chai*（并列通訊作者）,Yongming Wang*.Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition.PLoS Biology,20(11):e3001897, 2022(IF:9.593)
27. Hui Zhang, Jiahui Guo, Yu Wang, Luoran Shang*, Renjie Chai*（并列通訊作者）, Yuanjin Zhao*. Natural polymer-derived bio-scaffolds for peripheral nerve regeneration. Advanced Functional Materials, 2203829, 2022(IF:19.924)
28. Hui Zhang, Han Zhang, Huan Wang, Yuanjin Zhao*, Renjie Chai*（最後并列通訊作者）. Natural proteins-derived asymmetric porous conduit for peripheral nerve regeneration. Applied Materials Today,101431, 2022(IF:8.663)
29. Maohua Wang#, Ying Dong#, Song Gao#, Zhenhua Zhong, Cheng Cheng, Ruiying Qiang, Yuhua Zhang, Xinyi Shi, Xiaoyun Qian, Xia Gao, Bing Guan*, Chenjie Yu*, Youjun Yu*, Renjie Chai*（最後并列通訊作者）. Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea. Cellular and Molecular Life Sciences, 79(2):79, 2022(IF:9.207)
30. Pei Jiang#, Xiangyu Ma#, Shanying Han#*, Leyao Ma#, Jingru Ai, Leilei Wu, Yuan Zhang, Hairong Xiao, Mengyao Tian, W. Andy Tao*, Shasha Zhang*, Renjie Chai*（最後并列通訊作者）.Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth. Cellular and Molecular Life Sciences, 79(3):154, 2022(IF:9.207)
31. Fuping Qian#, Guanyun Wei#, Yajing Gao#, Xin Wang, Jie Gong, Chao Guo, Xiaoning Wang, Xu Zhang, Jinxiang Zhao, Cheng Wang, Mengting Xu, Yuebo Hu, Guoli Yin, Jiahui Kang, Renjie Chai*（并列通訊作者）, Gangcai Xie*, Dong Liu*. Single‑cell RNA‑sequencing of zebrafsh hair cells reveals novel genes potentially involved in hearing loss. Cellular and Molecular Life Sciences, 79(7):385, 2022(IF:9.207)
32. Rongrong Guo#, Miao Xiao#, Wanyu Zhao#, Shan Zhou, Yangnan Hu, Menghui Liao, Shengping Wang, Xiaowei Yang*, Renjie Chai*（并列通訊作者）, Mingliang Tang*. 2D Ti3C2Tx MXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells. Acta Biomaterialia, 139:105-117, 2022(IF:10.633) (ESI高被引論文)
33. Yangnan Hu#, Wei Chen#, Haiyan Yin#, Xiaoyan Chen, Jiaying Cai, Jiamin Guo, Shan Zhou, Renjie Chai*（并列通訊作者）, Mingliang Tang*.Super-aligned carbon nanotubes and GelMA hydrogel composite scaffolds promote spiral ganglion neuron growth and orientation.Materials Today Nano, 18,100181, 2022(IF：13.364)
34. Yige Li#, Yangnan Hu#, Hao Wei#, Wei Cao#, Yanru Qi , Shan Zhou , Panpan Zhang , Huawei Li*, Geng‑Lin Li*, Renjie Chai*（最後并列通訊作者）. Two-dimensional Ti3C2Tx MXene promotes electrophysiological maturation of neural circuits.Journal of Nanobiotechnology, 20(1):398, 2022(IF:9.429)
35. Jiaying Cai#, Hui Zhang#, Yangnan Hu#, Zhichun Huang#, Yan Wang, Yu Xia, Xiaoyan Chen, Jiamin Guo, Hong Cheng, Lin Xia, Weicheng Lu, Chen Zhang, Jingdun Xie*, Huan Wang*, Renjie Chai*（最後并列通訊作者）. GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair. Journal of Nanobiotechnology, 20(1):460, 2022(IF:9.429)
36. Yuan Zhang#, Shasha Zhang#*, Han Zhou, Xiangyu Ma, Leilei Wu, Mengyao Tian, Siyu Li, Xiaoyun Qian*, Xia Gao*, Renjie Chai*（最後并列通訊作者）. Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLOS Genetics,18(6):e1010232, 2022(IF:6.02)
37. Hao Wei#, Zhuoyue Chen#, Yangnan Hu#, Wei Cao#, Xiaofeng Ma, Chen Zhang, Xia Gao, Xiaoyun Qian*, Yuanjin Zhao*, Renjie Chai*（最後并列通訊作者）. Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth. Small, e2102062,2021 (IF: 15.153)（Small期刊當期封面論文，國家自然科學基金委推薦論文）
38. Changxiu Qu#, Chunyou Mao#, Peng Xiao#, Qingya Shen#, YaNi Zhong#, Fan Yang#,Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, RuJia Zhao, Junyan He,Ying Guan, Chao Zhang, Guihua Hou, PengJu Zhang, Guige Hou, Zijian Li, Xiao Yu, Renjie Chai*（并列通訊作者）, YouFei Guan, JinPeng Sun*, Yan Zhang*. Ligand recognition, unconventional activation,and G protein coupling of the prostaglandin E2receptor 2 (EP2). Science Advances,7(14):eabf1268,2021 (IF:14.957)
39. Wenwen Liu#, Lei Xu#, Xue Wang, Daogong Zhang, Gaoying Sun, Man Wang, Mingming Wang, Yuechen Han*, Renjie Chai*（并列通訊作者）, Haibo Wang*. PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.Autophagy, 1-23, 2021 (IF：13.391)（ESI高被引論文）
40. Zuhong He#, Ming Li#, Qiaojun Fang#, Fuling Liao#, Shengyu Zou, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Xiaoxiang Xu, Sen Chen, Yu Sun, Renjie Chai*（并列通訊作者）, Weijia Kong*. FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. Autophagy, 1-22, 2021 (IF：13.391) （ESI高被引論文）
41. Yan Chen#, Yuyan Gu#, Yige Li#, GengLin Lia, Renjie Chai*（并列通訊作者）, Wenyan Li*, Huawei Li*. Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea. Cell Reports,35(3):109016, 2021 (IF：9.995)（ESI高被引論文）
42. Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao*, Renjie Chai*（最後并列通訊作者）. Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide. Bioactive Materials, 27;6(6):1653-1662, 2021 (IF:16.874)
43. Yanru Yang, Bingbing Gao, Yangnan Hu, Hao Wei, Chen Zhang, Renjie Chai*（并列通訊作者）, Zhongze Gu*. Ordered inverse-opal scaffold based on bionic transpiration to create a biomimetic spine. Nanoscale, 10.1039/D1NR00731A, 2021 (IF:8.307)
44. Xiaolong Fu#, Yachun An#, Hongyang Wang#, Peipei Li, Jing Lin, Jia Yuan, Rongyu Yue, Yecheng Jin, Jiangang Gao*, Renjie Chai*（最後并列通訊作者）. Deficiency of Klc2 induces low-frequency sensorineural hearing loss in C57BL/6J mice and human. Molecular Neurobiology,DOI:s12035-021-02422-w, 2021(IF:5.682)（ESI高被引論文，熱點論文）
45. Shanying Han#, Yueshuang Xu#, Jie Sun, Yufeng Liu, Yuanjin Zhao*, Weiguo Tao*, Renjie Chai*（最後并列通訊作者）. Isolation and analysis of extra cellular vesicles in a Morpho butterfly wing-integrated micro vortex biochip. Biosensors and Bioelectronics, 154:112073, 2020 (IF:12.545)
46. Jiahui Guo, Yunru Yu, Lingyu Sun, Zhuohao Zhang, Yuanjin Zhao*, Renjie Chai*（并列通訊作者）, Keqing Shi*. Bio-inspired multicomponent carbon nanotube microfibers from microfluidics for supercapacitor. Chemical Engineering Journal 397:125517, 2020(IF:16.744)
47. Zuhong He#, Shengyu Zou#, Ming Li, Fuling Liao, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Dan Li, Xiaoxiang Xu, Sen Chen, Yu Sun*, Renjie Chai*（并列通訊作者）, Weijia Kong*.The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox Biology,28:101364, 2020 (IF:10.787) （Faculty1000推薦，ESI高被引論文）
48. Shasha Zhang#, Yuan Zhang, Lingna Guo, Zhong Zhang, Ying Dong, Buwei Shao, Jieyu Qi, Han Zhou, Weijie Zhu, Xiaoqian Yan, Guodong Hong, Liyan Zhang, Xiaoli Zhang, Mingliang Tang, Chunjie Zhao, Xia Gao, Renjie Chai*（唯一通訊作者）. Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea.Cellular and Molecular Life Sciences, 77(7), 1401-1419, 2020(IF: 9.207)（Faculty1000推薦，ESI高被引論文）
49. Han Zhou#, Xiaoyun Qian#, Nana Xu, Shasha Zhang, Guangjie Zhu, Yuan Zhang, Dingding Liu, Cheng Cheng, Xiaocheng Zhu, Yongze Liu, Ling Lu, Jie Tang*, Renjie Chai*（并列通訊作者）, Xia Gao*. Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice. Cell Death & Disease, 11(10):913, 2020(IF:9.685)
50. Keqi, Fan#, Yiyuan Li#, Haoli Wang, Xintao Mao, Jinxin Guo, Xintao Mao, Fei, Wang, Lingjie Huang, Yining Li,Xiangyu Ma, Zhengjun Gao, Wei Chen, Dandan Qian, Wenjin Xue, Qian Cao, Lei Zhang, Li Shen,Long Zhang, Chao Tong, Jiangyan Zhong, Wei Lu, Ling Lu, Ke-ming Ren, Guisheng Zhong, Yuan Wang,Mingliang Tang, XinHua Feng, Renjie Chai*（并列通訊作者）, Jin Jin*. Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behavior. Cell, 179,864–879, 2019(IF: 66.850)（Faculty1000推薦，Cell正刊年度最佳論文，國家自然科學基金委推薦論文）
51. Fangzhi Tan#*, Cenfeng Chu#, Jieyu Qi#, Wenyan Li#, Dan You, Ke Li, Xing Chen, Weidong Zhao, Cheng Cheng, Xiaoyi Liu, Yunbo Qiao, Bing Su, Shuijin He, Chao Zhong, Huawei Li*, Renjie Chai*（并列通訊作者）, Guisheng Zhong*. AAV-ie enables safe and efficient gene transfer to inner ear cells. Nature Communications, 10(1):3733, 2019(IF: 17.694)（國家自然科學基金委推薦論文）
52. Yan Liu#, Jieyu Qi#, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*（并列通訊作者）, Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, 5(4):eaav7803, 2019(IF: 14.957)
53. Jinping Zhao#, Mingliang Tang#, Jing Cao, Dan Ye, Xudong Guo, Jiajie Xi, Yi Zhou, Yuchen Xia, Jing Qiao, Renjie Chai*（并列通訊作者）, Xiaowei Yang* and Jiuhong Kang*. Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency. Advanced Science, 6(12):1802136, 2019 (IF:17.521)
54. Wenwen Liu, Xiaochen Xu, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Xue Wang, Shasha Zhang, Mingliang Tang, Jianfeng Li, Renjie Chai*（并列通訊作者）, Haibo Wang*.Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea.Antioxidants & Redox Signaling, 30(11):1389-1410, 2019 (IF:7.468)
55. Jieyu Qi#, Yan Liu#, Cenfeng Chu, Xin Chen, Weijie Zhu, Yilai Shu, Shuijin He*, Renjie Chai*（并列通訊作者）, Guisheng Zhong*. A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells. Cell Discovery, 5:12, 2019(IF:38.079)
56. Cheng Cheng#, Yunfeng Wang#, Luo Guo#, Xiaoling Lu#, Weijie Zhu, Muhammad Waqas, Liyan Zhang, Ling Lu, Junyan Gao, Mingliang Tang, Xia Gao*, Huawei Li*, Renjie Chai*（最後并列通訊作者）.Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea.Stem cell research & therapy, 10(1):365, 2019 (IF:8.079)
57. Zhongmin Liu#, Mingliang Tang#, Jinping Zhao, Renjie Chai*（并列通訊作者）, Jiuhong Kang*. Looking into the Future: Towards Advanced Three-Dimensional Biomaterials for Stem Cell-Based Regenerative Medicine. Advanced Materials, 1705388, 2018(IF:32.086)
58. Luoran Shang, Yunru Yu, Wei Gao, Yuetong Wang, Liangliang Qu, Ze Zhao, Renjie Chai*（并列通訊作者）, Yuanjin Zhao*. Bio-inspired Anisotropic Wettability Surface from Dynamic Ferrofluid Assembled Templates. Advanced Functional Materials,1705802,2018(IF:19.924)
59. Sana Shaikh, Fawad Rehman, Tianyu Du, Hui Jiang, Lihong Yin, Xuemei Wang*, Renjie Chai*（最後并列通訊作者）. Real-time Multimodal Bioimaging of Cancer Cells and Exosomes through Biosynthesized Iridium and Iron Nanoclusters.ACS Applied Materials & Interfaces, 10(31):26056-26063, 2018 (IF:10.383)
60. Zuhong He#, Lingna Guo#, Yilai Shu#, Qiaojun Fang, Han Zhou, Yongze Liu, Dingding Liu, Ling Lu, Xiaoli Zhang, Xiaoqiong Ding, Dong Liu, Mingliang Tang, Weijia Kong, Suhua Sha, Huawei Li*, Xia Gao*, Renjie Chai*（最後并列通訊作者）. Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy, 2:1-21, 2017(IF: 13.391)
61. Rongrong Guo#, Shasha Zhang#, Miao Xiao#, Fuping Qian, Zuhong He, Dan Li, Xiaoli Zhang, Huawei Li, Xiaowei Yang, Ming Wang, Renjie Chai*（并列通訊作者）, Mingliang Tang*.Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. Biomaterials, 106:193-204. 2016(IF:15.304)
62. Liman Liu#, Yan Chen#, Jieyu Qi Yanping Zhang, Yingzi He, Wenli Ni, Wen Li, Shasha Zhang, Shan Sun, Makoto Taketo, Lei Wang, Renjie Chai*（并列通訊作者）, Huawei Li*. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.Cell Death & Disease, 10;7:e2136, 2016(IF:9.685)
63. Xin Wang, Chang Chun Ling, Liping Li, Yinyin Qin, Jialing Qi, Xiaoyu Liu, Bo You, Yunwei Shi, Jie Zhang, Qiu Jiang, Hui Xu, Cheng Sun, Yiwen You, Renjie Chai*（并列通訊作者）, Dong Liu*.MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular Research, 110(1):140-50, 2016(IF:13.081)
64. Tian Wang#, Renjie Chai#（并列第一作者）, Grace Kim, Nicole Pham, Lina Jansson, Duc-Huy Nguyen, Bryan Kuo, Lindsey May, Jian Zuo, Lisa Cunningham, Alan Cheng*. Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatalmouse utricle. Nature Communications, 7;6:6613, 2015(IF: 17.694)
65. Renjie Chai#（并列第一作者）, Bryan Kuo#, Tian Wang, Eric Liaw, Anping Xia, Taha Jana, Zhiyong Liu, Makoto M. Taketo, John Oghalai, Roeland Nusse, Jian Zuo*, Alan Cheng*. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A, 109(21):8167-72, 2012 (IF:12.779)（Faculty1000推薦）
三、 專利：
1. 柴人傑、陳蔚、張莎莎、程誠、高下；一種GPA、Espin、Ikzf2小鼠模型的構建方法；專利号ZL202110194377.5，申請日期2021年2月20日，授權時間2022年8月16日；證書号第5388731号。
2. 柴人傑、趙遠錦、胡揚楠、陳卓玥、魏浩、洪國棟；一種基于蝴蝶鱗翅的導電神經導管及其制備方法；專利号 ZL202111643052.7，申請日期2021年12月29日，授權時間2022年7月19日；證書号第5323789号。
3. 柴人傑、洪國棟、高下、唐明亮、付小龍；一種生物因子及其在促進内耳毛細胞再生上的應用；專利号 ZL2020110060861.0，申請日期2020年09月30日，授權時間2022年4月22日；證書号第5098878号。
4. 柴人傑、齊潔玉、鐘桂生、談方志、高下、唐明亮、付小龍；一種促進耳蝸毛細胞再生的肽段Tr及其應用；專利号 ZL202011059153.5，申請日期2020年09月30日，授權時間2021年12月14日；證書号第4850375号
5. 錢曉雲、祁姝琪、高下、孫曉安、柴人傑；氧化石墨烯人工耳蝸電極；專利号：ZL201920820468.3，申請時間2019年6月03日，授權時間2020年6月19日；證書号第10768061号
6. 李華偉，于慧前，何英姿，孫珊，黎奧，柴人傑；賴氨酸特異性去甲基化酶1抑制劑的應用；專利号ZL201410058438.5, 申請時間2014年2月 20日，授權時間2016年8月24日；證書号第2192983号
三、學術獎勵：
1. 柴人傑、高下、靳津、鐘桂生、李文妍、舒易來、齊潔玉、何水金、唐明亮、張莎莎、李異媛、程誠、陸玲、陳鑫，賀祖宏；通過程序化人工耳蝸手術及毛細胞再生治療感音神經性耳聾的研究；中華醫學科技獎二等獎（第一完成人），2023
2. 孫宇，柴人傑，賀祖宏，陶永，任冬冬；内耳發育障礙及基因幹預機制；湖北省科學技術獎二等獎（第二完成人），2023
3. 柴人傑，第十七屆中國青年科技獎，（第一完成人）2022
4. 柴人傑，2022年度中國科協十大強國青年科學家，（第一完成人）2022
5. 柴人傑，教育部霍英東教育基金會高等院校青年科學獎一等獎（第一完成人），2022
6. 柴人傑，第八屆樹蘭醫學青年獎（第一完成人），2021
7. 李華偉，李文妍，柴人傑，陳岩，孫珊，倪文力，魯小玲，張彥平；基因重編程策略調控内耳幹細胞增殖與分化；教育部高等學校科學研究優秀成果獎（科學技術）自然科學獎一等獎（第三完成人），2020
8. 李華偉，唐冬梅，藍軍，陳林，王武慶，陳兵，孫珊，王海濤，柴人傑，李樹峰；數字化耳鳴診療裝備的研發及推廣；上海市技術發明一等獎（第九完成人），2020
9. 高下，柴人傑，錢曉雲，陸玲，陳傑，朱光潔，楊烨，楊霞，程誠；感音神經性耳聾的基礎與臨床研究；江蘇省科技進步獎三等獎（第二完成人），2020
10. 高下，柴人傑，錢曉雲，陳傑，楊烨，陸玲，朱光潔，周函，楊霞；程序化人工耳蝸手術及感音神經性耳聾的相關分子機制研究；江蘇省醫學科技獎一等獎（第二完成人），2019
11. 柴人傑，江蘇省青年科技獎（第一完成人），2020
12. 柴人傑，江蘇省青年十大科技之星，2020
