王蘇

王蘇 教授，博士生導師

電話： 025-83790967

E-mail: wangsu@seu.edu.cn

辦公地點： 南京市四牌樓2号，李文正樓北樓217室

個人簡介

2010于北京大學獲得學士學位，2015于美國堪薩斯大學醫學中心獲得博士學位，并在美國Stowers醫學研究所擔任博士生研究員。2017年加入bet356在线官方网站生命科學研究院擔任研究員，分别入選中組部海外高層次人才“青年項目”，江蘇省特聘教授，江蘇省雙創人才，江蘇省“六大人才高峰”高層次人才。

研究方向：神經幹細胞功能和中樞神經系統發育調控機制

神經幹細胞因其自我更新及分化的潛力，成為未來臨床治療多種神經退行性疾病的重要潛在治療方法。如何在活體中精确安全地調控神經幹細胞的命運決定是當今的主要研究熱點之一，也是制約其臨床應用的主要瓶頸之一。本課題組通過多種模式生物，研究内部命運決定因子和外部微環境對神經幹細胞功能和中樞神經系統發育的調控機制。

代表文獻：

1. Mengzhu Ou^#, Su Wang^#, Mingkuan Sun, Jinsong An, Huihui Lv, Xiankun Zeng, Steven X. Hou*, Wei Xie*.: The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction. Experimental Cell Research. 2019 Jan 15; 374(2):342-352. doi: 10.1016/j.yexcr.2018.12.008.

2. Tingting Gao^#, Xin Zhao^#, Chenchen Liu^#, Binbin Shao^#, Xi Zhang, Kai Li, Jinyang Cai, Su Wang*, Xiaoyan Huang*.: Somatic Angiotensin I-Converting Enzyme Regulates Self-Renewal of Mouse Spermatogonial Stem Cells Through the Mitogen-Activated Protein Kinase Signaling Pathway. Stem Cells and Development. 2018 Aug 1;27(15):1021-1032. doi: 10.1089/scd.2017.0287.

3. Xing Ma^#, Xiujuan Zhu, Yingying Han, Benjamin Story, Trieu Do, Xiaoqing Song, Su Wang, Ying Zhang, Marco Blanchette, Madelaine Gogol, Kate Hall, Allison Peak, Perera Anoja, Ting Xie*.: Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms. Developmental Cell. 2017 Apr 24; 41(2):157-169. e5. doi: 10.1016/j.devcel.2017.03.023.

4. Tinglin Lu^#, Su Wang^#, Yuan Gao, Ying Mao, Zhihao Yang, Luping Liu, Xiaoqing Song, Jianquan Ni, Ting Xie*.: COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development. 2015 Dec 15;142(24):4242-52.

5. Su Wang^#, Yuan Gao, Xiaoqing Song, Xing Ma, Xiujuan Zhu, Ying Mao, Zhihao Yang, Jianquan Ni, Hua Li, Kathryn E Malanowski, Perera Anoja, Jungeun Park, Jeff Haug, Ting Xie*.: Wnt Signaling-Mediated Redox Regulation Maintains the Germline Stem Cell Differentiation Niche. eLife. 2015 Oct 9; 4. doi: 10.7554/eLife.08174

6. Lei Pan^#, Su Wang^#, Tinglin Lu^#, Changjiang Weng, Xiaoqing Song, Joseph K. Park, Jin Sun, Zhi-HaoYang, JunjingYu, Hong Tang, Dennis M. McKearin, Daniel A. Chamovitz, Jianquan Ni，Ting Xie*.: Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014 Oct 9; 514(7521):233-6.

7. Xing Ma^#, Su Wang, Trieu Do, Xiaoqing Song, Mayu Inaba, Yoshiya Nishimoto, Lu-ping Liu,Yuan Gao, Ying Mao, Hui Li, William McDowell, Jungeun Park, Kate Malanowski, Allison Peak, Anoja Perera, Hua Li, Karin Gaudenz, Jeff Haug, Yukiko Yamashita, Haifan Lin, Jian-quan Ni, Ting Xie*.: Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. PLoS One. 2014 Mar 21; 9(3):e90267.

8. Xiaoxi Wang^#, Lei Pan^#, Su Wang^#, Jian Zhou, William McDowell, Jungeun Park, Jeff Haug, Karen Staehling, Hong Tang, Ting Xie*.: Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation. PLoS Genet. 2011 Dec 22; 7(12):e1002426.

9. Daniel Kirilly^#, Su Wang^#, Ting Xie*.: Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011 Dec; 138(23):5087-97.

10. Shuyi Chen^#, Su Wang, Ting Xie*.: Restricting self-renewal signals within the stem cell niche: multiple levels of control. Curr Opin Genet Dev. 2011 Dec; 21(6):684-9.