李默怡 副教授、博士生導師
電 話:
Email: limoyi@seu.edu.cn
辦公地點:李文正樓南204
個人簡介:
1996年9月 — 2000年6月 學士, 微生物專業,華中農業大學
2000年9月 — 2003年6月 碩士, 生化工程專業,華中科技大學
2003年8月 — 2008年5月 博士, 植物病理專業,佛羅裡達大學
2009年1月 — 2013年7月 博士後,佛羅裡達大學
2014年1月 — 2016年2月 博士後,bet356在线官方网站
2016年2月至今 副研究員,bet356在线官方网站
研究方向:
神經發育與退行性疾病的分子機理
環路發育及功能的遺傳控制機制
近期代表性論文:
Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477. * co-first author; # Co-corresponding author
Xing G*, Li M* (co-first author), Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W. Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457
Liang X, Liberti D, Li M, Kim YT, Hutchens A, Wilson R, Rollins JA. Oxaloacetate acetylhydrolase gene mutants of Sclerotinia sclerotiorum do not accumulate oxalic acid, but do produce limited lesions on host plants. (2015) Mol. Plant Pathol. 16: 559-571.
Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322
Lee KY*, Li M* (co-first author), Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900
Poulos MG, Batra R, Li M, Yuan Y, Zhang C, Darnell RB and Swanson MS. Progressive impairment of muscle regeneration in muscleblind-like 3 Isoform knockout mice. (2013) Hum. Mol. Genet. 22: 3547-3558
Warren SA, Briggs LE, Zeng H, Chuang J, Chang Eileen, Terada R, Li M, Swanson MS, Wood CE, Spinale FG, Maupine-Furlow J, McMullen JR, Moss R, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. (2012) Circulation. 126: 2575-2588
Li M, Liang X, and Rollins JA. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420
Li M and Rollins JA. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538
Li M and Rollins JA. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43