韓俊海

個人簡介：  

 1995年9月-1999年月     南京大學，生物化學專業，本科；

 1999年9月-2004年7月    南京大學，分子生物學與生物化學專業，碩博連讀；

 2004年7月-2008年8月    美國麻州大學醫學院，神經生物學，博士後；

 2008年8月-2019年6月    bet356在线官方网站，生命科學研究院，教授；

 2019年6月-現在         bet356在线官方网站，beat365体育官网平台，教授。

研究方向：孤獨症緻病機制研究

     兒童孤獨症譜系障礙是一種常見的神經發育障礙性疾病，其發病率約1%。孤獨症的核心臨床症狀包括社會交往障礙和重複呆闆的動作，不同的孤獨症患者還伴随如智力障礙、癫痫、睡眠障礙等臨床症狀。目前人們對于兒童孤獨症的緻病機制尚不完全清楚。本實驗室以果蠅和小鼠為模式動物，運用生物化學與分子生物學、細胞生物學、遺傳學、神經生物學、電生理學及行為學解析孤獨症風險因子的分子功能及孤獨症的緻病機制。

近期代表性論文：（* 通訊作者; # 第一作者）

1. Jin X^#, Tian Y^#, Zhang ZC, Gu P, Liu C, Han J* (2021). A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Curr Biol. Online, doi: 10.1016/j.cub.2021.02.048.

2.Shen Y^#, Zhang ZC^#,*, Cheng S^#, Liu A, Zuo J, Xia S, Liu X, Liu W, Jia Z, Xie W, Han J* (2021). PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell, online, doi: 10.1016/j.molcel.2021.01.032.

3. Wu J, Ji X, Gu Q, Liao B, Dong W*, Han J* (2021). Parallel Synaptic Acetylcholine Signals Facilitate Large Monopolar Cell Repolarization and Modulate Visual Behavior in Drosophila. J Neurosci. 41:2164-2176.

4. Gu Q^#, Wu J^#, Tian Y, Cheng S, Zhang ZC*, Han J*(2021).Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila. J Biol Chem. 295:5554-5563. (Cover Story).

5.Mu Y, Tian Y, Zhang ZC*, Han J* (2019). Metallophosphoesterase regulates light-induced rhodopsin endocytosis by promoting an association between arrestin and the adaptor protein AP2. J Biol Chem. 294:12892-12900. (Cover Story).

6. Li Q^#, Li Y^#, Wang X^#, Qi J, Jin X, Tong H, Zhou Z, Zhang ZC, Han J* (2017). Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA_A Receptor.Curr Biol. 

   27:3616-3625.

7. Liu L^#, Tian Y^#, Zhang XY, Zhang X, Li T, Xie W, Han J* (2017). Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering.Dev Cell.41:94-106. (Cover Story)

8. Wang X^#, Mu Y, Sun M, Han J* (2017). Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.J Mol Cell Biol. 9:104-116.

9. Tong H^#, Li Q, Zhang ZC, Li Y, Han J* (2016). Neurexin regulates nighttime sleep by modulating synaptic transmission.Sci Rep. 6:38246.

10. Wan D^#, Zhang ZC^#, Zhang X, Li Q, Han J* (2015). X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs.Hum Mol Genet. 24:4599-614

11. Li T^#, Tan Y, Li Q, Chen H, Lv H, Xie W, Han J* (2015). The Neurexin-NSF interaction regulates short-term synaptic depression.J Biol Chem. 290:17656-67. (Cover Story).

12. Hu W^#, Wang T, Wang X, and Han J* (2015). I_h Channels Control Feedback Regulation from Amacrine Cells to Photoreceptors. PLoS Biology. 13:e1002115.

13. Li Y^#, Zhou Z^#, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W*, Han J* (2013). Drosophila Neuroligin 4 Regulates Sleep through Modulating GABA Transmission.  J Neurosci. 33:15545-54.

14. Tian Y^#, Li T, Sun M, Wan D, Li Q, Li P, Zhang Z, Han J*, Wei Xie* (2013). Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron 77: 311-322.

15. Hu W^#, Wan D, Yu X, Cao J, Guo P, Li HS, Han J* (2012). Protein Gq modulates termination of phototransduction and prevents retinal degeneration. J Biol Chem 287:13911-8.

16. Cao J^#, Li Y^#, Xia W, Reddig K, Hu W, Xie W, Li HS*, Han J* (2011). A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. EMBO J 30: 3701-13.

17. Han J^#, Reddig K and Li HS* (2007). Prolonged Gq activity triggers fly rhodopsin endocytosis and degradation and reduces photoreceptor sensitivity. EMBO J 26:4966-73.

18. Han J^#, Gong P^#, Reddig K^#, Mitra M, Guo P and Li HS* (2006). The fly CAMTA transcription factor potentiates deactivation of the G protein-coupled light receptor rhodopsin. Cell 127: 847-858.