華旭  江蘇特聘教授，博士生導師

E-mail: xhua@seu.edu.cn

辦公地點： bet356在线官方网站江北校區彙川樓B座406

個人簡介：

本科畢業于南京理工大學（應用物理學專業），博士畢業于南京大學（生物信息學方向），期間在德國哥廷根大學訪學兩年。随後于美國MD Anderson癌症研究中心和哥倫比亞大學任博士後和副研究科學家。2024年入職bet356在线官方网站，任上崗研究員、博士生導師，獲江蘇省特聘教授。

研究方向：

長期專注于遺傳學與生物信息學的交叉研究，開發幹濕結合的新技術，采用跨學科的方法解決遺傳學的關鍵科學問題并獲得一系列代表性成果：1）表觀遺傳記憶在親本-子代細胞之間的傳遞機制及其在細胞表型方面的重要作用。2）遺傳突變在癌症中的作用機制。采用系統生物學和多組學的方法揭示了癌症相關突變在基因調控網絡中的擾動機制，發現非編碼區上的關鍵遺傳突變的作用。3）開發基于表觀遺傳學、遺傳學的癌症無創診斷新技術。已在Nature、Molecular Cell、Science Advances、Nature communications、Cancer Discovery等高水平期刊發表論文20餘篇，研究成果在Nature、Cell等著名期刊上被丹麥科學院院士、歐洲科學院院士等多次引用。

代表性論文：

1. Albert Serra-Cardona^*, Xu Hua^*, Seth W. McNutt, Hui Zhou, Takenori Toda, Songtao Jia, Feixia Chu, and Zhiguo Zhang. The PCNA-Pol delta complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Science Advances,2024

2. Yimeng Fang^*, Xu Hua^*, Chun-Min Shan, Takenori Toda, Feng Qiao, Zhiguo Zhang, and Songtao Jia. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. Genes Development, 2024, doi:10.1101/gad.351278.123 （封面文章）

3. Xu Hua^*, Yongsheng Li^*, Sairahul R. Pentaparthi^*, Daniel J. McGrail^*, Raymond Zou^*, Li Guo^*, Aditya Shrawat, Kara M. Cirillo, Qing Li, Akshay Bhat, Min Xu, Dan Qi, Ashok Singh, Francis McGrath, Steven Andrews, Kyaw Lwin Aung, Jishnu Das, Yunyun Zhou, Alessia Lodi, Gordon B. Mills, S. Gail Eckhardt, Marc L. Mendillo, Stefano Tiziani, Erxi Wu⁺, Jason H. Huang⁺, Nidhi Sahni⁺, and S. Stephen Yi⁺. Landscape of microRNA regulatory network architecture and functional rerouting in cancer. Cancer Research, 2023, 83, 59-73

4. Zhiming Li^*, Shoufu Duan^*, Xu Hua, Xiaowei Xu, Yinglu Li, Demis Menolfi, Hui Zhou, Chao Lu, Shan Zha, Stephen P. Goff, Zhiguo Zhang⁺. Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements. Nature, 2023, vol623, 643-651

5.  Xiaowei Xu^*, Xu Hua^*, Kyle Brown, Xiaojun Ren and Zhiguo Zhang⁺. Mcm2 promotes stem cell differentiation via its ability to bind H3-H4. eLife, 2022, 11, e80917

6.  Zhiming Li^*, Xu Hua^*, Albert Serra-Cardona, Xiaowei Xu, Zhiguo Zhang⁺. Efficient and strand-specific profiling of replicating chromatin with eSPAN in mammalian cells. Nature Protocols, 2021, 16, 2698–2721

7.  Zhiming Li^*, Xu Hua^*, Albert Serra-Cardona^*, Xiaowei Xu^*, Songlin Gan, Hui Zhou, Wen-Si Yang, Chun-long Chen, Rui-Ming Xu, and Zhiguo Zhang⁺. DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. Science Advances, 2020, Vol. 6, no. 35, eabb5820

8. Xu Hua^*, Tang Rongjun^*, Xu Xiuxiu, Wang Zhi, Xu Qi, Chen Luxiao, Wingender Edgar, Li Jie⁺, Chenyu Zhang⁺ and Wang Jin⁺. mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines. Nucleic Acids Research, 2018,Volume 46, Issue D1, 4

9. Xu Hua, Luxiao Chen, Jin Wang⁺, Jie Li⁺ and Edgar Wingender⁺. Identifying cell-specific microRNA transcriptional start sites. Bioinformatics, 2016,Volume 32, Issue 16, Pages 2403–2410

10. Jie Li^*, Xu Hua^*, Martin Haubrock, Jin Wang⁺ and Edgar Wingender⁺. The architecture of the gene regulatory networks of different tissues. Bioinformatics, 2012, Volume 28, Issue 18, Pages i509–i514

招生與招聘：

歡迎具有遺傳學、表觀遺傳學、生物化學、細胞生物學、分子生物學或生物信息學等專業背景的碩士生、博士生、博士後加入本團隊，熟悉ChIP-Seq、MeDIP-Seq、CUT&RUN、單細胞測序、文庫構建等經驗的優先考慮。